Evidence map›Paper›PMID 28364287›Full record

ReviewEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2017

How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?

Fernando López, Michelle D Williams, Antonio Cardesa, Jennifer L Hunt, Primož Strojan, Alessandra Rinaldo, Iain J Nixon, Juan P Rodrigo, Nabil F Saba, William M Mendenhall and 3 more

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. The histopathological spectrum of laryngeal epithelial neoplasia.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Definitive RadiotherapyInternational archives of otorhinolaryngology · 2022
    Article
  9. Article
  10. Rare Diseases of Larynx, Trachea and Thyroid.Laryngo- rhino- otologie · 2021
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 5 countries.

Fernando LópezDepartment of Otolaryngology, Hospital Universitario Central de Asturias, Avenida de Roma s/n, 33011, Oviedo (Asturias), Spain. flopez_1981@yahoo.es.ORCID http://orcid.org/0000-0001-7019-9746
Michelle D WilliamsDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Antonio CardesaDepartment of Anatomic Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain.
Jennifer L HuntDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Primož StrojanDepartment of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia.
Alessandra RinaldoUniversity of Udine School of Medicine, Udine, Italy.
Iain J NixonDepartments of Surgery and Otolaryngology, Head and Neck Surgery, Edinburgh University, Edinburgh, UK.
Juan P RodrigoDepartment of Otolaryngology, Hospital Universitario Central de Asturias, Avenida de Roma s/n, 33011, Oviedo (Asturias), Spain.
Nabil F SabaDepartment of Hematology and Medical Oncology, The Winship Cancer Institute of Emory University, Atlanta, GA, USA.
William M MendenhallDepartment of Radiation Oncology, University of Florida, Gainesville, FL, USA.
Miquel QuerDepartment of Otolaryngology, Hospital Santa Creu i Sant Pau, Barcelona, Spain.
Carlos SuárezInstituto Universitario de Oncología del Principado de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias and CIBERONC, ISCIII, University of Oviedo, Oviedo, Spain.
Alfio FerlitoInternational Head and Neck Scientific Group, Padua, Italy.
Universidad de Oviedo · ESEmory University · USHospital de Sant Pau · ESHospital Universitario Central de Asturias · ESInstitute of Oncology Ljubljana · SIThe University of Texas MD Anderson Cancer Center · USUniversitat de Barcelona · ESUniversity of Arkansas for Medical Sciences · USUniversity of Edinburgh · GBUniversity of Florida · USUniversity of Udine · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the majority of laryngeal malignancies are the conventional squamous cell carcinomas (SCC), a wide variety of malignant epithelial tumors can affect the larynx. Current treatment guidelines are designed to guide clinicians in management of conventional laryngeal SCC. Less is known about the biological behavior and responsiveness to therapy and overall outcomes of other malignant epithelial lesions. Because a spectrum of disease biology is represented by these rare phenotypes, an understanding of the basic biology can help direct management to optimize clinical outcome in this group of patients. This review provides a critical analysis of literature relating to the diagnosis, management, and outcome of patients with non-conventional squamous malignant epithelial neoplasms of the larynx. Particular attention is paid to features which are at variance with the conventional SCC and how these impact on management of these rare tumors.

Indexed as

Carcinoma, Squamous CellHumansLaryngeal NeoplasmsLarynxPhenotypeAcantholytic squamous cell carcinomaAdenosquamous carcinoma larynxBasaloid squamous cell carcinomaHistologyLaryngeal cancerLymphoepithelial carcinomaNon-keratinizing HPV-positive squamous cell carcinomaPapillary squamous cell carcinomaSpindle cell carcinomaVerrucous squamous cell carcinoma

Identifiers

PMID28364287
OpenAlexW2597933562

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.