ArticleBreast cancer research and treatment2017
Frailty and long-term mortality of older breast cancer patients: CALGB 369901 (Alliance).
Article in Breast cancer research and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.
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Who cites it
57 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Frequency of use and characterization of frailty assessments in observational studies on older women with breast cancer: a systematic review.BMC geriatrics · 2024Pooled it
- Comprehensive Geriatric Assessment for Older Women with Early-Stage (Non-Metastatic) Breast Cancer-An Updated Systematic Review of the Literature.Current oncology (Toronto, Ont.) · 2023Pooled it
- The prevalence of frailty among breast cancer patients: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Pooled it
- Trial
- The Relationship Between Frailty and Emotional Health in Older Patients with Advanced Cancer.The oncologist · 2021Trial
- Frailty and associated factors in women aged 65 years and older with breast cancer: a cross-sectional study.BMC geriatrics · 2026Article
- Clinically Meaningful, Patient-Centered Endpoints for Real-World Evidence Generation in Breast Cancer: Perspectives from the Multidisciplinary TRIUMPH Initiative.Advances in therapy · 2026Article
- Association between frailty and breast cancer incidence and construction of a breast cancer prediction model based on machine learning.Frontiers in public health · 2026Article
- Development and validation of a risk prediction model for postoperative frailty in breast cancer patients.PeerJ · 2026Article
- Breast cancer-specific survival by molecular subtype in different age groups of women in Scotland.Breast cancer research : BCR · 2025Article
- Depressive symptom trajectories in older breast cancer survivors: the Thinking and Living with Cancer Study.Journal of cancer survivorship : research and practice · 2025Article
- Frailty Trajectories Following Adjuvant Chemotherapy and Mortality in Older Women With Breast Cancer.JAMA network open · 2025Article
- Impact of Lookback Duration on the Performance of a Claims-Based Frailty Proxy in Women With Stage I-III Breast Cancer.Pharmacoepidemiology and drug safety · 2025Article
- Impact of Pre-Existing Frailty on Cardiotoxicity Among Breast Cancer Patients Receiving Adjuvant Therapy.JACC. CardioOncology · 2025Article
- Longitudinal trajectories of a claims-based frailty measure during adjuvant chemotherapy in women with stage I-III breast cancer.The oncologist · 2024Article
- Avoiding Locoregional Overtreatment in Older Adults With Early-Stage Breast Cancer.Clinical breast cancer · 2024Review
- Plant Foods Intake and Risk of Premature Aging in Adult Survivors of Childhood Cancer in the St Jude Lifetime Cohort (SJLIFE).Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Article
- Deficit Accumulation Index and Biological Markers of Aging in Survivors of Childhood Cancer.JAMA network open · 2023Article
- How frail is frail in oncology studies? A scoping review.BMC cancer · 2023Article
- Pectoralis muscle index might be a factor associated with frailty in older women with breast cancer.Turkish journal of medical sciences · 2023Observational
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14 authors.
Funding
Abstract
purposeBreast cancer patients aged 65+ ("older") vary in frailty status. We tested whether a deficits accumulation frailty index predicted long-term mortality.
methodsOlder patients (n = 1280) with non-metastatic, invasive breast cancer were recruited from 78 Alliance sites from 2004 to 2011, with follow-up to 2015. Frailty categories (robust, pre-frail, and frail) were based on 35 baseline illness and function items. Cox proportional hazards and competing risk models were used to calculate all-cause and breast cancer-specific mortality for up to 7 years, respectively. Potential covariates included demographic, psychosocial, and clinical factors, diagnosis year, and care setting.
resultsPatients were 65-91 years old. Most (76.6%) were robust; 18.3% were pre-frail, and 5.1% frail. Robust patients tended to receive more chemotherapy ± hormonal therapy (vs. hormonal) than pre-frail or frail patients (45% vs. 37 and 36%, p = 0.06), and had the highest adherence to hormonal therapy. The adjusted hazard ratios for all-cause mortality (n = 209 deaths) were 1.7 (95% CI 1.2-2.4) and 2.4 (95% CI 1.5-4.0) for pre-frail and frail versus robust women, respectively, with an absolute mortality difference of 23.5%. The adjusted hazard of breast cancer death (n-99) was 3.1 (95% CI 1.6-5.8) times higher for frail versus robust patients (absolute difference of 14%). Treatment differences did not account for the relationships between frailty and mortality.
conclusionsMost older breast cancer patients are robust and could consider chemotherapy where otherwise indicated. Patients who are frail or pre-frail have elevated long-term all-cause and breast cancer mortality. Frailty indices could be useful for treatment decision-making and care planning with older patients.
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