ArticleScientific reports2017
'Two-level' measurements of processing speed as cognitive markers in the differential diagnosis of DSM-5 mild neurocognitive disorders (NCD).
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 16 citations in OpenAlex.
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- Diversity in verbal fluency performance and its associations with MRI-informed brain age matrices in normal ageing and neurocognitive disorders.CNS neuroscience & therapeutics · 2023Article
- Multifactorial structure of cognitive assessment tests in the UK Biobank: A combined exploratory factor and structural equation modeling analyses.Frontiers in psychology · 2023Article
- A dual-task-embedded virtual reality system for intelligent quantitative assessment of cognitive processing speed.Frontiers in human neuroscience · 2023Article
- The Influence of Processing Speed, Attention, and Inhibition on Texas Functional Living Scale Performance.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2022Article
- Neuroimaging and biomarker evidence of neurodegeneration in asthma.The Journal of allergy and clinical immunology · 2022Article
- Validity and Cultural Generalisability of a 5-Minute AI-Based, Computerised Cognitive Assessment in Mild Cognitive Impairment and Alzheimer's Dementia.Frontiers in psychiatry · 2021Article
- A culturally fair test of processing speed: Construct validity, preliminary normative data, and effects of HIV infection on performance in South African adults.Neuropsychology · 2019Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Processing speed is an updated diagnostic factor for neurocognitive disorders (NCD) in DSM-5. This study investigated the characteristics of processing speed and their diagnostic values in NCD patients. A flanker test was conducted in 31 adults with NCD due to vascular disease (NCD-vascular), 36 patients with NCD due to Alzheimer's disease (NCD-AD), and 137 healthy controls. The processing speed was evaluated using two measurements: mean reaction time (RT) and intra-individual variability of RT. Mean RT represents the global processing speed. Intra-individual variability of RT is the short-term fluctuation of RT and consists of two indices, which are intra-individual coefficient of variation of reaction time (ICV-RT) and intra-individual standard deviations (iSD). We observed elevated ICV-RT and iSD in NCD-AD and NCD-vascular patients. Additionally, there was a slowed RT in NCD-AD patients. The intra-individual variability of RT had a moderate power to differentiate NCD subgroups. The mean RT was able to discriminate the NCD-AD from NCD-vascular patients. Our findings highlight the clinical utility of the combined 'two-level' measurements of processing speed to distinguish between individuals with different cognitive status. Furthermore, the 'two-level' features of processing speed embedded in the psychometric property may also reflect the diverse aetiology underlying certain 'disease-specific' neurocognitive disorders.
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