Evidence map›Paper›PMID 28364091›Full record

Trial reportCirculation. Heart failure2017

Effect of Intensive Blood Pressure Treatment on Heart Failure Events in the Systolic Blood Pressure Reduction Intervention Trial.

Bharathi Upadhya, Michael Rocco, Cora E Lewis, Suzanne Oparil, Laura C Lovato, William C Cushman, Jeffrey T Bates, Natalie A Bello, Gerard Aurigemma, Lawrence J Fine and 8 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation. Heart failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01206062 (Systolic Blood Pressure Intervention Trial), which is not on this map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01206062 nacompletednot on this map

Systolic Blood Pressure Intervention Trial

TypeinterventionalSponsorNational Heart, Lung, and Blood Institute (NHLBI)Ran2010 to 2019Enrolled9,361ConditionsHypertensionArmsIntensive control of SBP, Standard control of SBP
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 115 citations in OpenAlex.

  1. Guideline
  2. Guideline
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Impact of Antihypertensive Drug Class on Outcomes in SPRINT.Hypertension (Dallas, Tex. : 1979) · 2022
    Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Heart failure with preserved ejection fraction.Nature reviews. Disease primers · 2024
    Review
  18. Review
  19. Review
  20. Preventing new-onset heart failure: Intervening at stage A.American journal of preventive cardiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Bharathi UpadhyaFrom the Cardiovascular Medicine Section (B.U., C.J.R., D.W.K.), Nephrology Section, Department of Internal Medicine (M.R.), and Biostatistics (L.C.L.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Preventive Medicine (C.E.L.) and Division of Cardiovascular Disease (S.O.), Department of Medicine, University of Alabama, Birmingham; Preventive Medicine Section, Veterans Affairs Medical Center, Memphis, TN (W.C.C.); Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX (J.T.B.); Cardiovascular Division, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Department of Cardiology, University of Massachusetts Medical School, Worcester (G.A.); Clinical Applications and Prevention Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (L.J.F.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J.); Department of Medicine-Nephrology, George Washington University School of Medicine, DC (D.S.R.); Division of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (A.R.); University of Miami Miller School of Medicine, FL and Veterans Affairs Medical Center, Miami, FL (L.T.); and UH Harrington Heart and Vascular Institute, Cleveland Medical Center, OH (A.W.).
Michael RoccoFrom the Cardiovascular Medicine Section (B.U., C.J.R., D.W.K.), Nephrology Section, Department of Internal Medicine (M.R.), and Biostatistics (L.C.L.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Preventive Medicine (C.E.L.) and Division of Cardiovascular Disease (S.O.), Department of Medicine, University of Alabama, Birmingham; Preventive Medicine Section, Veterans Affairs Medical Center, Memphis, TN (W.C.C.); Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX (J.T.B.); Cardiovascular Division, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Department of Cardiology, University of Massachusetts Medical School, Worcester (G.A.); Clinical Applications and Prevention Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (L.J.F.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J.); Department of Medicine-Nephrology, George Washington University School of Medicine, DC (D.S.R.); Division of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (A.R.); University of Miami Miller School of Medicine, FL and Veterans Affairs Medical Center, Miami, FL (L.T.); and UH Harrington Heart and Vascular Institute, Cleveland Medical Center, OH (A.W.).
Cora E LewisFrom the Cardiovascular Medicine Section (B.U., C.J.R., D.W.K.), Nephrology Section, Department of Internal Medicine (M.R.), and Biostatistics (L.C.L.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Preventive Medicine (C.E.L.) and Division of Cardiovascular Disease (S.O.), Department of Medicine, University of Alabama, Birmingham; Preventive Medicine Section, Veterans Affairs Medical Center, Memphis, TN (W.C.C.); Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX (J.T.B.); Cardiovascular Division, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Department of Cardiology, University of Massachusetts Medical School, Worcester (G.A.); Clinical Applications and Prevention Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (L.J.F.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J.); Department of Medicine-Nephrology, George Washington University School of Medicine, DC (D.S.R.); Division of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (A.R.); University of Miami Miller School of Medicine, FL and Veterans Affairs Medical Center, Miami, FL (L.T.); and UH Harrington Heart and Vascular Institute, Cleveland Medical Center, OH (A.W.).
Suzanne OparilFrom the Cardiovascular Medicine Section (B.U., C.J.R., D.W.K.), Nephrology Section, Department of Internal Medicine (M.R.), and Biostatistics (L.C.L.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Preventive Medicine (C.E.L.) and Division of Cardiovascular Disease (S.O.), Department of Medicine, University of Alabama, Birmingham; Preventive Medicine Section, Veterans Affairs Medical Center, Memphis, TN (W.C.C.); Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX (J.T.B.); Cardiovascular Division, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Department of Cardiology, University of Massachusetts Medical School, Worcester (G.A.); Clinical Applications and Prevention Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (L.J.F.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J.); Department of Medicine-Nephrology, George Washington University School of Medicine, DC (D.S.R.); Division of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (A.R.); University of Miami Miller School of Medicine, FL and Veterans Affairs Medical Center, Miami, FL (L.T.); and UH Harrington Heart and Vascular Institute, Cleveland Medical Center, OH (A.W.).
Laura C LovatoFrom the Cardiovascular Medicine Section (B.U., C.J.R., D.W.K.), Nephrology Section, Department of Internal Medicine (M.R.), and Biostatistics (L.C.L.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Preventive Medicine (C.E.L.) and Division of Cardiovascular Disease (S.O.), Department of Medicine, University of Alabama, Birmingham; Preventive Medicine Section, Veterans Affairs Medical Center, Memphis, TN (W.C.C.); Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX (J.T.B.); Cardiovascular Division, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Department of Cardiology, University of Massachusetts Medical School, Worcester (G.A.); Clinical Applications and Prevention Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (L.J.F.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J.); Department of Medicine-Nephrology, George Washington University School of Medicine, DC (D.S.R.); Division of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (A.R.); University of Miami Miller School of Medicine, FL and Veterans Affairs Medical Center, Miami, FL (L.T.); and UH Harrington Heart and Vascular Institute, Cleveland Medical Center, OH (A.W.).
William C CushmanFrom the Cardiovascular Medicine Section (B.U., C.J.R., D.W.K.), Nephrology Section, Department of Internal Medicine (M.R.), and Biostatistics (L.C.L.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Preventive Medicine (C.E.L.) and Division of Cardiovascular Disease (S.O.), Department of Medicine, University of Alabama, Birmingham; Preventive Medicine Section, Veterans Affairs Medical Center, Memphis, TN (W.C.C.); Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX (J.T.B.); Cardiovascular Division, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Department of Cardiology, University of Massachusetts Medical School, Worcester (G.A.); Clinical Applications and Prevention Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (L.J.F.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J.); Department of Medicine-Nephrology, George Washington University School of Medicine, DC (D.S.R.); Division of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (A.R.); University of Miami Miller School of Medicine, FL and Veterans Affairs Medical Center, Miami, FL (L.T.); and UH Harrington Heart and Vascular Institute, Cleveland Medical Center, OH (A.W.).
Jeffrey T BatesFrom the Cardiovascular Medicine Section (B.U., C.J.R., D.W.K.), Nephrology Section, Department of Internal Medicine (M.R.), and Biostatistics (L.C.L.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Preventive Medicine (C.E.L.) and Division of Cardiovascular Disease (S.O.), Department of Medicine, University of Alabama, Birmingham; Preventive Medicine Section, Veterans Affairs Medical Center, Memphis, TN (W.C.C.); Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX (J.T.B.); Cardiovascular Division, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Department of Cardiology, University of Massachusetts Medical School, Worcester (G.A.); Clinical Applications and Prevention Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (L.J.F.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J.); Department of Medicine-Nephrology, George Washington University School of Medicine, DC (D.S.R.); Division of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (A.R.); University of Miami Miller School of Medicine, FL and Veterans Affairs Medical Center, Miami, FL (L.T.); and UH Harrington Heart and Vascular Institute, Cleveland Medical Center, OH (A.W.).
Natalie A BelloFrom the Cardiovascular Medicine Section (B.U., C.J.R., D.W.K.), Nephrology Section, Department of Internal Medicine (M.R.), and Biostatistics (L.C.L.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Preventive Medicine (C.E.L.) and Division of Cardiovascular Disease (S.O.), Department of Medicine, University of Alabama, Birmingham; Preventive Medicine Section, Veterans Affairs Medical Center, Memphis, TN (W.C.C.); Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX (J.T.B.); Cardiovascular Division, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Department of Cardiology, University of Massachusetts Medical School, Worcester (G.A.); Clinical Applications and Prevention Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (L.J.F.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J.); Department of Medicine-Nephrology, George Washington University School of Medicine, DC (D.S.R.); Division of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (A.R.); University of Miami Miller School of Medicine, FL and Veterans Affairs Medical Center, Miami, FL (L.T.); and UH Harrington Heart and Vascular Institute, Cleveland Medical Center, OH (A.W.).
Gerard AurigemmaFrom the Cardiovascular Medicine Section (B.U., C.J.R., D.W.K.), Nephrology Section, Department of Internal Medicine (M.R.), and Biostatistics (L.C.L.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Preventive Medicine (C.E.L.) and Division of Cardiovascular Disease (S.O.), Department of Medicine, University of Alabama, Birmingham; Preventive Medicine Section, Veterans Affairs Medical Center, Memphis, TN (W.C.C.); Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX (J.T.B.); Cardiovascular Division, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Department of Cardiology, University of Massachusetts Medical School, Worcester (G.A.); Clinical Applications and Prevention Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (L.J.F.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J.); Department of Medicine-Nephrology, George Washington University School of Medicine, DC (D.S.R.); Division of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (A.R.); University of Miami Miller School of Medicine, FL and Veterans Affairs Medical Center, Miami, FL (L.T.); and UH Harrington Heart and Vascular Institute, Cleveland Medical Center, OH (A.W.).
Lawrence J FineFrom the Cardiovascular Medicine Section (B.U., C.J.R., D.W.K.), Nephrology Section, Department of Internal Medicine (M.R.), and Biostatistics (L.C.L.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Preventive Medicine (C.E.L.) and Division of Cardiovascular Disease (S.O.), Department of Medicine, University of Alabama, Birmingham; Preventive Medicine Section, Veterans Affairs Medical Center, Memphis, TN (W.C.C.); Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX (J.T.B.); Cardiovascular Division, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Department of Cardiology, University of Massachusetts Medical School, Worcester (G.A.); Clinical Applications and Prevention Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (L.J.F.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J.); Department of Medicine-Nephrology, George Washington University School of Medicine, DC (D.S.R.); Division of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (A.R.); University of Miami Miller School of Medicine, FL and Veterans Affairs Medical Center, Miami, FL (L.T.); and UH Harrington Heart and Vascular Institute, Cleveland Medical Center, OH (A.W.).
Karen C JohnsonFrom the Cardiovascular Medicine Section (B.U., C.J.R., D.W.K.), Nephrology Section, Department of Internal Medicine (M.R.), and Biostatistics (L.C.L.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Preventive Medicine (C.E.L.) and Division of Cardiovascular Disease (S.O.), Department of Medicine, University of Alabama, Birmingham; Preventive Medicine Section, Veterans Affairs Medical Center, Memphis, TN (W.C.C.); Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX (J.T.B.); Cardiovascular Division, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Department of Cardiology, University of Massachusetts Medical School, Worcester (G.A.); Clinical Applications and Prevention Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (L.J.F.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J.); Department of Medicine-Nephrology, George Washington University School of Medicine, DC (D.S.R.); Division of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (A.R.); University of Miami Miller School of Medicine, FL and Veterans Affairs Medical Center, Miami, FL (L.T.); and UH Harrington Heart and Vascular Institute, Cleveland Medical Center, OH (A.W.).
Carlos J RodriguezFrom the Cardiovascular Medicine Section (B.U., C.J.R., D.W.K.), Nephrology Section, Department of Internal Medicine (M.R.), and Biostatistics (L.C.L.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Preventive Medicine (C.E.L.) and Division of Cardiovascular Disease (S.O.), Department of Medicine, University of Alabama, Birmingham; Preventive Medicine Section, Veterans Affairs Medical Center, Memphis, TN (W.C.C.); Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX (J.T.B.); Cardiovascular Division, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Department of Cardiology, University of Massachusetts Medical School, Worcester (G.A.); Clinical Applications and Prevention Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (L.J.F.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J.); Department of Medicine-Nephrology, George Washington University School of Medicine, DC (D.S.R.); Division of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (A.R.); University of Miami Miller School of Medicine, FL and Veterans Affairs Medical Center, Miami, FL (L.T.); and UH Harrington Heart and Vascular Institute, Cleveland Medical Center, OH (A.W.).
Dominic S RajFrom the Cardiovascular Medicine Section (B.U., C.J.R., D.W.K.), Nephrology Section, Department of Internal Medicine (M.R.), and Biostatistics (L.C.L.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Preventive Medicine (C.E.L.) and Division of Cardiovascular Disease (S.O.), Department of Medicine, University of Alabama, Birmingham; Preventive Medicine Section, Veterans Affairs Medical Center, Memphis, TN (W.C.C.); Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX (J.T.B.); Cardiovascular Division, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Department of Cardiology, University of Massachusetts Medical School, Worcester (G.A.); Clinical Applications and Prevention Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (L.J.F.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J.); Department of Medicine-Nephrology, George Washington University School of Medicine, DC (D.S.R.); Division of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (A.R.); University of Miami Miller School of Medicine, FL and Veterans Affairs Medical Center, Miami, FL (L.T.); and UH Harrington Heart and Vascular Institute, Cleveland Medical Center, OH (A.W.).
Anjay RastogiFrom the Cardiovascular Medicine Section (B.U., C.J.R., D.W.K.), Nephrology Section, Department of Internal Medicine (M.R.), and Biostatistics (L.C.L.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Preventive Medicine (C.E.L.) and Division of Cardiovascular Disease (S.O.), Department of Medicine, University of Alabama, Birmingham; Preventive Medicine Section, Veterans Affairs Medical Center, Memphis, TN (W.C.C.); Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX (J.T.B.); Cardiovascular Division, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Department of Cardiology, University of Massachusetts Medical School, Worcester (G.A.); Clinical Applications and Prevention Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (L.J.F.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J.); Department of Medicine-Nephrology, George Washington University School of Medicine, DC (D.S.R.); Division of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (A.R.); University of Miami Miller School of Medicine, FL and Veterans Affairs Medical Center, Miami, FL (L.T.); and UH Harrington Heart and Vascular Institute, Cleveland Medical Center, OH (A.W.).
Leonardo TamarizFrom the Cardiovascular Medicine Section (B.U., C.J.R., D.W.K.), Nephrology Section, Department of Internal Medicine (M.R.), and Biostatistics (L.C.L.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Preventive Medicine (C.E.L.) and Division of Cardiovascular Disease (S.O.), Department of Medicine, University of Alabama, Birmingham; Preventive Medicine Section, Veterans Affairs Medical Center, Memphis, TN (W.C.C.); Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX (J.T.B.); Cardiovascular Division, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Department of Cardiology, University of Massachusetts Medical School, Worcester (G.A.); Clinical Applications and Prevention Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (L.J.F.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J.); Department of Medicine-Nephrology, George Washington University School of Medicine, DC (D.S.R.); Division of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (A.R.); University of Miami Miller School of Medicine, FL and Veterans Affairs Medical Center, Miami, FL (L.T.); and UH Harrington Heart and Vascular Institute, Cleveland Medical Center, OH (A.W.).
Alan WiggersFrom the Cardiovascular Medicine Section (B.U., C.J.R., D.W.K.), Nephrology Section, Department of Internal Medicine (M.R.), and Biostatistics (L.C.L.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Preventive Medicine (C.E.L.) and Division of Cardiovascular Disease (S.O.), Department of Medicine, University of Alabama, Birmingham; Preventive Medicine Section, Veterans Affairs Medical Center, Memphis, TN (W.C.C.); Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX (J.T.B.); Cardiovascular Division, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Department of Cardiology, University of Massachusetts Medical School, Worcester (G.A.); Clinical Applications and Prevention Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (L.J.F.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J.); Department of Medicine-Nephrology, George Washington University School of Medicine, DC (D.S.R.); Division of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (A.R.); University of Miami Miller School of Medicine, FL and Veterans Affairs Medical Center, Miami, FL (L.T.); and UH Harrington Heart and Vascular Institute, Cleveland Medical Center, OH (A.W.).
Dalane W KitzmanFrom the Cardiovascular Medicine Section (B.U., C.J.R., D.W.K.), Nephrology Section, Department of Internal Medicine (M.R.), and Biostatistics (L.C.L.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Preventive Medicine (C.E.L.) and Division of Cardiovascular Disease (S.O.), Department of Medicine, University of Alabama, Birmingham; Preventive Medicine Section, Veterans Affairs Medical Center, Memphis, TN (W.C.C.); Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX (J.T.B.); Cardiovascular Division, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Department of Cardiology, University of Massachusetts Medical School, Worcester (G.A.); Clinical Applications and Prevention Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (L.J.F.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J.); Department of Medicine-Nephrology, George Washington University School of Medicine, DC (D.S.R.); Division of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (A.R.); University of Miami Miller School of Medicine, FL and Veterans Affairs Medical Center, Miami, FL (L.T.); and UH Harrington Heart and Vascular Institute, Cleveland Medical Center, OH (A.W.). dkitzman@wakehealth.edu.
SPRINT Research Group
Veterans Health Administration · US

Funding

INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR024134 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$70.4M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Institutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9M
Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Denise Kathryn Houston · 2002 to 2026
$36.4M
Tufts Clinical and Translational Research InstituteUL1TR001064 · NCATS · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2013 to 2017
$26.4M
University of Iowa Clinical and Translational Science Program (TL1)UL1RR025755 · NCRR · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2008 to 2011
$26.3M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025771 · NCRR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CENTER, DAVID M. · 2008 to 2011
$17.6M
TUFTS CLINICAL AND TRANSLATION SCIENCE INSTITUTE (UL1): BPCAUL1RR025752 · NCRR · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2008 to 2011
$17.6M
Clinical and Translational Science Institute at Children's NationalUL1TR000075 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2012 to 2015
$13.7M
NCATS NIH HHS UL1 TR000002NCATS NIH HHS UL1 TR000003NCATS NIH HHS UL1 TR000005NCATS NIH HHS UL1 TR000050NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR000073NCATS NIH HHS UL1 TR000075NCATS NIH HHS UL1 TR000093NCATS NIH HHS UL1 TR000105NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR001064NCRR NIH HHS UL1 RR024134NCRR NIH HHS UL1 RR025752NCRR NIH HHS UL1 RR025755NCRR NIH HHS UL1 RR025771NHLBI NIH HHS HHSN268200900040CNHLBI NIH HHS HHSN268200900046CNHLBI NIH HHS HHSN268200900047CNHLBI NIH HHS HHSN268200900048CNHLBI NIH HHS HHSN268200900049CNHLBI NIH HHS R01 HL107257NIA NIH HHS P30 AG021332NIA NIH HHS R01 AG018915NIA NIH HHS R01 AG020583NIA NIH HHS R01 AG045551NIGMS NIH HHS P30 GM103337
6 · The paper itself

Abstract

backgroundAcute decompensated heart failure (ADHF) was a frequent common outcome in SPRINT (Systolic Blood Pressure Intervention Trial). We examined whether there was differential reduction in ADHF events from intensive blood pressure [BP] treatment among the 6 key, prespecified subgroups in SPRINT: age ≥75 years, prior cardiovascular disease, chronic kidney disease, women, black race, and 3 levels of baseline systolic BP (≤132 versus >132 to <145 versus ≥145 mm Hg). METHODS AND

resultsADHF was defined as hospitalization for ADHF, confirmed and formally adjudicated by a blinded events committee using standardized protocols. At 3.29 years follow-up, there were 103 ADHF events (2.2%) among 4683 standard arm participants and 65 ADHF events (1.4%) among 4678 intensive arm participants (Cox proportional hazards ratio, 0.63; 95% confidence interval, 0.46-0.85;

conclusionsTargeting a systolic BP<120 mm Hg, compared with <140 mm Hg, significantly reduced ADHF events, and the benefit was similar across all key, prespecified subgroups. Participants who developed ADHF had markedly increased risk for subsequent cardiovascular events and death, highlighting the importance of strategies aimed at prevention of ADHF, especially intensive BP reduction. CLINICAL

trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01206062.

Indexed as

AgedAged, 80 and overAntihypertensive AgentsBlood PressureChi-Square DistributionComorbidityFemaleHeart FailureHospitalizationHumansHypertensionKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisProportional Hazards ModelsAntihypertensive Agentsagingclinical trialheart failurehypertensionwomen and minorities

Identifiers

PMID28364091
PMCPMC5384646
OpenAlexW2601765095

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.