ReviewAmerican journal of physiology. Heart and circulatory physiology2017
Recording sympathetic nerve activity in conscious humans and other mammals: guidelines and the road to standardization.
Review in American journal of physiology. Heart and circulatory physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 1 synthesis or guideline pooled it, 157 citations in OpenAlex.
- Guidelines for authors and reviewers on antibody use in physiology studies.American journal of physiology. Heart and circulatory physiology · 2018Guideline
- Binge Alcohol Consumption Elevates Sympathetic Transduction to Blood Pressure: A Randomized Controlled Trial.Hypertension (Dallas, Tex. : 1979) · 2024Trial
- Simultaneous noninvasive recording of electrocardiogram and skin sympathetic nerve activity (neuECG).Nature protocols · 2020Trial
- Role of the carotid chemoreceptors in insulin-mediated sympathoexcitation in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Trial
- Reducing Dietary Sodium to 1000 mg per Day Reduces Neurovascular Transduction Without Stimulating Sympathetic Outflow.Hypertension (Dallas, Tex. : 1979) · 2019Trial
- Carotid chemoreflex activity restrains post-exercise cardiac autonomic control in healthy humans and in patients with pulmonary arterial hypertension.The Journal of physiology · 2019Trial
- Guidelines for rigor and reproducibility of heart rate variability within human cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2026Review
- Acute intermittent hypercapnic hypoxia augments left ventricular contractility.The Journal of physiology · 2026Article
- Heart Rate Variability Moderates the Association Between Trait Anxiety and Sympathetic Nerve Activity in Humans.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Autonomic cardiovascular mechanisms linked to stress in dental practice.British dental journal · 2026Review
- Zilebesiran: an RNA interference agent-its need and potential to transform hypertension treatment.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026Review
- Technologies to investigate the mechanisms of force-based manipulations: a narrative methods review.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Blunted baroreflex-mediated sympathoinhibition and vasodilation to countdown before exercise in young women compared to men.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Vasomotor symptoms of menopause, sympathetic activity, and blood pressure in postmenopausal females.American journal of physiology. Heart and circulatory physiology · 2025Article
- Sympathetic reactivity to physiological stress is associated with expanded cardiac extracellular volume in humans.BMC medicine · 2025Article
- Review
- Activation of Sympathetic Nervous System Drives Dry Eye Onset Via Norepinephrine-β2-Adrenergic Receptor Signaling in Mice.Investigative ophthalmology & visual science · 2025Article
- Differential effects of female aging on sympathetic blood pressure regulation at rest and during stress in humans.Physiological reports · 2025Article
- Association between skin sympathetic nerve activity and electrocardiogram alterations after subarachnoid hemorrhage.Physiological reports · 2025Article
- Renal autonomic dynamics in hypertension: how can we evaluate sympathetic activity for renal denervation?Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 9 institutions in 5 countries.
Funding
Abstract
Over the past several decades, studies of the sympathetic nervous system in humans, sheep, rabbits, rats, and mice have substantially increased mechanistic understanding of cardiovascular function and dysfunction. Recently, interest in sympathetic neural mechanisms contributing to blood pressure control has grown, in part because of the development of devices or surgical procedures that treat hypertension by manipulating sympathetic outflow. Studies in animal models have provided important insights into physiological and pathophysiological mechanisms that are not accessible in human studies. Across species and among laboratories, various approaches have been developed to record, quantify, analyze, and interpret sympathetic nerve activity (SNA). In general, SNA demonstrates "bursting" behavior, where groups of action potentials are synchronized and linked to the cardiac cycle via the arterial baroreflex. In humans, it is common to quantify SNA as bursts per minute or bursts per 100 heart beats. This type of quantification can be done in other species but is only commonly reported in sheep, which have heart rates similar to humans. In rabbits, rats, and mice, SNA is often recorded relative to a maximal level elicited in the laboratory to control for differences in electrode position among animals or on different study days. SNA in humans can also be presented as total activity, where normalization to the largest burst is a common approach. The goal of the present paper is to put together a summary of "best practices" in several of the most common experimental models and to discuss opportunities and challenges relative to the optimal measurement of SNA across species.Listen to this article's corresponding podcast at https://ajpheart.podbean.com/e/guidelines-for-measuring-sympathetic-nerve-activity/.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.