Evidence map›Paper›PMID 28363977›Full record

ArticleGenetics2017

Facilitating Neuron-Specific Genetic Manipulations in

Michael-John Dolan, Haojiang Luan, William C Shropshire, Ben Sutcliffe, Benjamin Cocanougher, Robert L Scott, Shahar Frechter, Marta Zlatic, Gregory S X E Jefferis, Benjamin H White

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
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  11. The Q-system: A Versatile Repressible Binary Expression System.Methods in molecular biology (Clifton, N.J.) · 2022
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. TheFrontiers in neural circuits · 2020
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Michael-John DolanDivision of Neurobiology, Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, CB2 0QH, United Kingdom.
Haojiang LuanLaboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892.
William C ShropshireLaboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892.
Ben SutcliffeDivision of Neurobiology, Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, CB2 0QH, United Kingdom.
Benjamin CocanougherJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147.
Robert L ScottLaboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892.
Shahar FrechterDivision of Neurobiology, Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, CB2 0QH, United Kingdom.
Marta ZlaticJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147.
Gregory S X E JefferisDivision of Neurobiology, Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, CB2 0QH, United Kingdom.ORCID 0000-0002-0587-9355
Benjamin H WhiteLaboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 benjaminwhite@mail.nih.gov.ORCID 0000-0003-0612-8075
National Institutes of Health · USHoward Hughes Medical Institute · USMRC Laboratory of Molecular Biology · GB

Funding

Identifying Neural Substrates of Behavior in Drosophila MelanogasterZIAMH002800 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI WHITE, BENJAMIN H · 2009 to 2025
$29.2M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
European Research Council 211089Howard Hughes Medical InstituteIntramural NIH HHS ZIA MH002800Medical Research Council MC_U105188491NIH HHS P40 OD018537
6 · The paper itself

Abstract

Efforts to map neural circuits have been galvanized by the development of genetic technologies that permit the manipulation of targeted sets of neurons in the brains of freely behaving animals. The success of these efforts relies on the experimenter's ability to target arbitrarily small subsets of neurons for manipulation, but such specificity of targeting cannot routinely be achieved using existing methods. In

Indexed as

AnimalsDNA-Binding ProteinsDrosophila melanogasterDrosophila ProteinsGene Expression Regulation, DevelopmentalNeuronsRepressor ProteinsTranscription FactorsDNA-Binding ProteinsDrosophila ProteinsGAL4 protein, DrosophilaRepressor ProteinsTranscription FactorsDrosophilaGal4-UASLexA-LexAopneural circuitstransgene expression

Identifiers

PMID28363977
PMCPMC5499185
OpenAlexW2602878009

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.