ArticleDrug and alcohol dependence2017
Providing chronic pain management in the "Fifth Vital Sign" Era: Historical and treatment perspectives on a modern-day medical dilemma.
Article in Drug and alcohol dependence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
120 citing papers in PubMed, 3 syntheses or guidelines pooled it, 253 citations in OpenAlex.
- Music-based interventions for chronic pain management.The Cochrane database of systematic reviews · 2026Pooled it
- A multi-ancestry genetic study of pain intensity in 598,339 veterans.Nature medicine · 2024Pooled it
- Acupuncture Therapy as an Evidence-Based Nonpharmacologic Strategy for Comprehensive Acute Pain Care: The Academic Consortium Pain Task Force White Paper Update.Pain medicine (Malden, Mass.) · 2022Pooled it
- Task-dependent functional connectivity of pain is associated with the magnitude of placebo analgesia in pain-free individuals.European journal of pain (London, England) · 2023Trial
- Trial
- Development and Testing of a Mobile App for Pain Management Among Cancer Patients Discharged From Hospital Treatment: Randomized Controlled Trial.JMIR mHealth and uHealth · 2019Trial
- Telementoring for improving primary care provider knowledge and competence in managing chronic pain: A randomised controlled trial.Journal of telemedicine and telecareTrial
- From the Pain Matrix to Functional Networks: A Narrative Review of Chronic Pain Mechanisms Across Adult and Pediatric Populations with Emerging AI Perspectives.Brain sciences · 2026Review
- Nano-Enhanced Optical Delivery of Multi-Characteristic Opsin Gene for Spinal Optogenetic Modulation of Pain.Bioengineering (Basel, Switzerland) · 2026Article
- Do Must-Access Prescription Drug Monitoring Programs (PDMPs) Affect Pain and Impairment Outcomes in Older Adults?Medical care research and review : MCRR · 2026Article
- The Economic burden of opioid-related serious adverse events and undertreatment of acute pain in the United States.Frontiers in public health · 2026Review
- Tailoring an auricular point acupressure self-management program for chronic pain: lessons learned from rural partners.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Diagnosis, Prognosis, and Drug Target Discovery for Chronic Widespread Pain: A Large Proteogenomic Study.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The Impact of Medical Cannabis Laws on Cannabis and Opioid Use Disorder Treatment and Overdose-Related Health Care Utilization Among Adults With Chronic Noncancer Pain.The Milbank quarterly · 2025Article
- A Literature Review on Pain Management in Women During Medical Procedures: Gaps, Challenges, and Recommendations.Medicina (Kaunas, Lithuania) · 2025Review
- Trends in Pain Care for Patients with Chronic Low Back Pain Between 2012 and 2021.Journal of general internal medicine · 2025Article
- Article
- The Two Sides of Placebo Analgesia: Differential Functional Connectivity Reveals Mechanisms of Placebo Analgesic Response.Journal of pain research · 2025Article
- "Do Doctors and Patients Have Different Understandings of Pain?" - A Pilot Study of Different Perspectives and Understandings of Pain in Clinical Pain Research.Journal of pain research · 2025Article
- Effects of training on Feline Grimace Scale scoring for acute pain assessment in cats.Journal of feline medicine and surgery · 2024Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundOver 100 million Americans are living with chronic pain, and pain is the most common reason that patients seek medical attention. Despite the prevalence of pain, the practice of pain management and the scientific discipline of pain research are relatively new fields compared to the rest of medicine - contributing to a twenty-first century dilemma for health care providers asked to relieve suffering in the "Fifth Vital Sign" era.
methodsThis manuscript provides a narrative review of the basic mechanisms of chronic pain and history of chronic pain management in the United States - including the various regulatory, health system and provider factors that contributed to the decline of multidisciplinary pain treatment in favor of the predominant opioid treatment strategy seen today. Multiple non-opioid pain treatment strategies are then outlined. The manuscript concludes with three key questions to help guide future research at the intersection of pain and addiction.
conclusionsThe assessment and treatment of chronic pain will continue to be one of the most common functions of a health care provider. To move beyond an over reliance on opioid medications, the addiction and pain research communities must unite with chronic pain patients to increase the evidence base supporting non-opioid analgesic strategies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.