Evidence map›Paper›PMID 28362926›Full record

ArticleNeurosurgery2017

Launching Effectiveness Research to Guide Practice in Neurosurgery: A National Institute Neurological Disorders and Stroke Workshop Report.

Patricia Walicke, Aviva Abosch, Anthony Asher, Fred G Barker, Zoher Ghogawala, Robert Harbaugh, Lara Jehi, John Kestle, Walter Koroshetz, Roderick Little and 5 more

Abstract readConference Proceedings
In one paragraph

Article in Neurosurgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Patricia WalickeNational Institute Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
Aviva AboschDepartment of Neurosurgery, University of Colorado-Anschutz Medical Campus, Aurora, Co-lorado.
Anthony AsherDepartment of Neurosurgery and Neuroscience Institute, Carolinas Healthcare System, Charlotte, North Caro-lina.
Fred G BarkerDepartment of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts.
Zoher GhogawalaAlan L. and Jacqueline B. Stuart Spine Research Center, Depart-ment of Neurosurgery, Lahey Hospital and Medical Center, Burlington, Massa-chusetts; Tufts University School of Medi-cine, Boston, Massachusetts.
Robert HarbaughDepart-ment of Neurosurgery, Penn State University, Milton S. Hershey Medical Center, Hershey, Pennsylvania.
Lara JehiEpilepsy Center, Cleveland Clinic, Cleveland, Ohio.
John KestleDepartment of Neurosurgery, University of Utah, Salt Lake City, Utah.
Walter KoroshetzNational Institute Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
Roderick LittleBiostatistics, University of Michi-gan, Ann Arbor, Michigan.
Donald RubinDepartment of Statistics, Harvard University, Cam-bridge, Massachusetts.
Alex ValadkaDepartment of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia.
Stephen WisniewskiDepart-ment of Epidemiology, University of Pittsburg, Pittsburgh, Pennsylvania.
E Antonio ChioccaDepartment of Neurosurgery, Brigham and Women's Hospital, Center for Neuro- Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Workshop Participants

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This workshop addressed challenges of clinical research in neurosurgery. Randomized controlled clinical trials (RCTs) have high internal validity, but often insufficiently generalize to real-world practice. Observational studies are inclusive but often lack sufficient rigor. The workshop considered possible solutions, such as (1) statistical methods for demonstrating causality using observational data; (2) characteristics required of a registry supporting effectiveness research; (3) trial designs combining advantages of observational studies and RCTs; and (4) equipoise, an identified challenge for RCTs. In the future, advances in information technology potentially could lead to creation of a massive database where clinical data from all neurosurgeons are integrated and analyzed, ending the separation of clinical research and practice and leading to a new "science of practice."

Indexed as

Clinical Trials as TopicGuidelines as TopicResearch DesignAcademies and InstitutesBiomedical ResearchHumansNeurosurgeryNeurosurgical ProceduresClinical trialsEffectiveness researchEquipoiseRandomized controlled trialRegistry

Identifiers

PMID28362926
PMCPMC5808147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.