SynthesisPloS one2017
Supervised exercise training versus usual care in ambulatory patients with left ventricular assist devices: A systematic review.
Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Exercise rehabilitation in ventricular assist device recipients: a meta-analysis of effects on physiological and clinical outcomes.Heart failure reviews · 2019Pooled it
- Exercise-based cardiac rehabilitation for people with implantable ventricular assist devices.The Cochrane database of systematic reviews · 2018Pooled it
- Pooled it
- LVAD Pump Flow Does Not Adequately Increase With Exercise.Artificial organs · 2019Trial
- The role of cardiac rehabilitation in improving cardiovascular outcomes.Nature reviews. Cardiology · 2022Review
- Muscle strength, aerobic capacity, and exercise tolerance are impaired in left ventricular assist devices recipients: A pilot study.Frontiers in physiology · 2022Article
- HFA of the ESC position paper on the management of LVAD-supported patients for the non-LVAD specialist healthcare provider Part 3: at the hospital and discharge.ESC heart failure · 2021Article
- Cardiac Rehabilitation in German Speaking Countries of Europe-Evidence-Based Guidelines from Germany, Austria and Switzerland LLKardReha-DACH-Part 2.Journal of clinical medicine · 2021Review
- Short- and long-term effects of a cardiac rehabilitation program in patients implanted with a left ventricular assist device.PloS one · 2021Observational
- The Future of Exercise-Based Cardiac Rehabilitation for Patients With Heart Failure.Frontiers in cardiovascular medicine · 2021Review
- Approaches to improving exercise capacity in patients with left ventricular assist devices: an area requiring further investigation.Expert review of medical devices · 2019Review
- Exercise in Heart Failure-What Is the Optimal Dose to Improve Pathophysiology and Exercise Capacity?Current heart failure reports · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Implantation of left ventricular assist devices (LVAD) has increased because of improved safety profile and limited availability of heart transplantation. Although supervised exercise training (ET) programs are known to improve exercise capacity and quality of life (QoL) in heart failure (HF) patients, similar data is inconclusive in LVAD patients. Thus, we performed a systematic review on studies that incorporated supervised ET and measured peak oxygen uptake in LVAD patients. A total of 150 patients in exercise and 55 patients in control groups were included from 8 studies selected from our predefined criteria. Our systematic review suggests supervised ET has an inconsistent effect on exercise capacity and QoL when compared to control groups undergoing usual care. A quantitative sub-analysis was performed with 4 studies that provided enough data to compare peak oxygen uptake and QoL at baseline and at follow-up. After at least 6 weeks of training, LVAD patients undergoing supervised ET demonstrated significant improvement in exercise capacity (standardized mean difference [SMD] = 0.735, 95% Confidence Interval-[CI], 0.31-1.15 units of the standard deviation, P = 0.001) and QoL scores (SMD = 1.58, 95% CI 0.97-2.20 units of the standard deviation, P <0.001) when compared to the usual care group, with no serious adverse events with exercise. These results suggest that supervised ET is safe and can improve patient outcomes in LVAD patients when compared to the usual care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.