Evidence map›Paper›PMID 28362550›Full record

ArticleHuman vaccines & immunotherapeutics2017

Are children's vitamin D levels and BMI associated with antibody titers produced in response to 2014-2015 influenza vaccine?

Chyongchiou J Lin, Judith M Martin, Kelly Stefano Cole, Richard K Zimmerman, Michael Susick, Krissy K Moehling, Min Z Levine, Sarah Spencer, Brendan Flannery, Mary Patricia Nowalk

Open access · bronzeAbstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
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  6. Review
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  8. Article
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  11. Vitamin D and Influenza-Prevention or Therapy?International journal of molecular sciences · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Chyongchiou J Lina Department of Family Medicine , University of Pittsburgh , Pittsburgh , PA , USA.
Judith M Martinb Department of Pediatrics , University of Pittsburgh , Pittsburgh , PA , USA.
Kelly Stefano Colec Department of Immunology and Center for Vaccine Research , University of Pittsburgh , Pittsburgh , PA, USA.
Richard K Zimmermana Department of Family Medicine , University of Pittsburgh , Pittsburgh , PA , USA.
Michael Susicka Department of Family Medicine , University of Pittsburgh , Pittsburgh , PA , USA.
Krissy K Moehlinga Department of Family Medicine , University of Pittsburgh , Pittsburgh , PA , USA.
Min Z Levined Influenza Division , Centers for Disease Control and Prevention , Atlanta , GA , USA.
Sarah Spencerd Influenza Division , Centers for Disease Control and Prevention , Atlanta , GA , USA.
Brendan Flanneryd Influenza Division , Centers for Disease Control and Prevention , Atlanta , GA , USA.
Mary Patricia Nowalka Department of Family Medicine , University of Pittsburgh , Pittsburgh , PA , USA.
University of Pittsburgh · USCenters for Disease Control and Prevention · USAtlanta Research and Education Foundation · US

Funding

UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
NCATS NIH HHS UL1 TR000005NCRR NIH HHS UL1 RR024153
6 · The paper itself

Abstract

backgroundVitamin D is an immunomodulating hormone, which has been associated with susceptibility to infectious diseases.

methodsSerum vitamin D levels in 135 children ages 3-17 y were measured at baseline and hemagglutinin influenza antibody titers were measured pre- and 21 d post influenza vaccination with live attenuated influenza vaccine (LAIV) or inactivated influenza vaccine (IIV). Height and weight were derived from the electronic medical record and were used to calculate body mass index (BMI).

resultsThirty-nine percent of children were ages 3-8 years; 75% were black, 34% were obese (BMI ≥ 95

conclusionLow vitamin D levels were associated with higher response to LAIV B lineages in the 2014-2015 LAIV, but not related to LAIV A or any IIV strains.

Indexed as

Antibody FormationBody Mass IndexAdolescentAntibodies, ViralChildChild, PreschoolFemaleHumansInfluenza VaccinesMaleVaccines, AttenuatedVaccines, InactivatedVitamin DAntibodies, ViralInfluenza VaccinesVaccines, AttenuatedVaccines, InactivatedVitamin Dantibodiesimmunogenicityinfluenza vaccineobesityvitamin D

Identifiers

PMID28362550
PMCPMC5512779
OpenAlexW2597918986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.