ReviewThe British journal of radiology2017
Multiple sclerosis update: use of MRI for early diagnosis, disease monitoring and assessment of treatment related complications.
Review in The British journal of radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Incorporation of the central vein sign into the McDonald criteria.Multiple sclerosis and related disorders · 2025Article
- Gastroparesis-An Often-Overlooked Sign of Multiple Sclerosis: Case Report.Case reports in immunology · 2025Article
- Article
- Current and Future Developments in Imaging and Treatment of White Matter Disease: A Systematic Review.Cureus · 2023Review
- An atypical case of progressive multifocal leukoencephalopathy in a patient with high grade B-cell lymphoma causing diagnostic delay.JRSM open · 2023Article
- Multiple Sclerosis in a Patient With Neurogenic Locus Notch Homolog Protein 3 Mutation.Journal of clinical neurology (Seoul, Korea) · 2023Article
- Recent advances in the longitudinal segmentation of multiple sclerosis lesions on magnetic resonance imaging: a review.Neuroradiology · 2022Review
- Serum levels of irisin and nesfatin-1 in multiple sclerosis.Arquivos de neuro-psiquiatria · 2022Article
- A Quantitative Synthesis of Eight Decades of Global Multiple Sclerosis Research Using Bibliometrics.Frontiers in neurology · 2022Review
- Juxtacortical susceptibility changes in progressive multifocal leukoencephalopathy at the gray-white matter junction correlates with iron-enriched macrophages.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021Article
- Impact of Moderate Individually Tailored Physical Activity in Multiple Sclerosis Patients with Fatigue on Functional, Cognitive, Emotional State, and Postural Stability.Brain sciences · 2021Article
- Subtyping relapsing-remitting multiple sclerosis using structural MRI.Journal of neurology · 2021Article
- Review
- Platelets in Multiple Sclerosis: Early and Central Mediators of Inflammation and Neurodegeneration and Attractive Targets for Molecular Imaging and Site-Directed Therapy.Frontiers in immunology · 2021Review
- Neurofilament light chain as a biomarker for diagnosis of multiple sclerosis.EXCLI journal · 2021Review
- Blood Neurofilament Light Chain: The Neurologist's Troponin?Biomedicines · 2020Review
- Association between urinary symptom severity and white matter plaque distribution in women with multiple sclerosis.Neurourology and urodynamics · 2020Article
- Chronic inflammation in multiple sclerosis - seeing what was always there.Nature reviews. Neurology · 2019Review
- Neurological safety of fingolimod: An updated review.Clinical & experimental neuroimmunology · 2017Review
- Progressive Multifocal Leukoencephalopathy and Immune Reconstitution Inflammatory Syndrome after Discontinuation of Fingolimod.Case reports in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MRI has long been established as the most sensitive in vivo technique for detecting multiple sclerosis (MS) lesions. The 2010 revisions of the McDonald Criteria have simplified imaging criteria, such that a diagnosis of MS can be made on a single contrast-enhanced MRI scan in the appropriate clinical context. New disease-modifying therapies have proven effective in reducing relapse rate and severity. Several of these therapies, most particularly natalizumab, but also dimethyl fumarate and fingolimod, have been associated with progressive multifocal leukoencephalopathy (PML). PML-immune reconstitution inflammatory syndrome (IRIS) has been recognized in patients following cessation of natalizumab owing to PML, and discontinuation for other reasons can lead to the phenomenon of rebound MS. These complications often provide a diagnostic dilemma and have implications for imaging surveillance of patients. We demonstrate how the updated McDonald Criteria aid the diagnosis of MS and describe the imaging characteristics of conditions such as PML and PML-IRIS in the context of MS. Potential imaging surveillance protocols are considered for the diagnosis and assessment of complications. We will explain how changes in MS treatment are leading to new imaging demands in order to monitor patients for disease progression and treatment-related complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.