Evidence map›Paper›PMID 28362395›Full record

ArticleJournal of visualized experiments : JoVE2017

A Novel Technique for Generating and Observing Chemiluminescence in a Biological Setting.

Gabriel E Büchel, Brandon Carney, Jun Tang, Brian M Zeglis, Jörg Eppinger, Thomas Reiner

Abstract readVideo-Audio Media
In one paragraph

Article in Journal of visualized experiments : JoVE, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gabriel E BüchelDepartment of Radiology, Memorial Sloan Kettering Cancer Center; KAUST Catalysis Center, King Abdullah University of Science and Technology.
Brandon CarneyDepartment of Radiology, Memorial Sloan Kettering Cancer Center; Department of Chemistry, Hunter College, and PhD Program in Chemistry, Graduate Center of City University of New York.
Jun TangDepartment of Radiology, Memorial Sloan Kettering Cancer Center.
Brian M ZeglisDepartment of Radiology, Memorial Sloan Kettering Cancer Center; Department of Chemistry, Hunter College, and PhD Program in Chemistry, Graduate Center of City University of New York.
Jörg EppingerKAUST Catalysis Center, King Abdullah University of Science and Technology.
Thomas ReinerDepartment of Radiology, Memorial Sloan Kettering Cancer Center; Department of Radiology, Weill Cornell Medical College; reinert@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Clinical and Translational Science CenterUL1TR000457 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2012 to 2016
$46.0M
Pretargeted Radioimmunotherapy Based on Bioorthogonal Click ChemistryR00CA178205 · NCI · HUNTER COLLEGE · PI ZEGLIS, BRIAN MATTHEW · 2015 to 2017
$747k
Bioorthogonal Strategies for Targeted PET Imaging Probe DevelopmentK25EB016673 · NIBIB · SLOAN-KETTERING INST CAN RESEARCH · PI REINER, THOMAS · 2013 to 2015
$525k
Development of Nuclear Auger Emitters for Targeted RadiotherapyR21CA191679 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI REINER, THOMAS, WEBER, WOLFGANG · 2015 to 2016
$187k
NCATS NIH HHS UL1 TR000457NCI NIH HHS P30 CA008748NCI NIH HHS R00 CA178205NCI NIH HHS R21 CA191679NIBIB NIH HHS K25 EB016673
6 · The paper itself

Abstract

Intraoperative imaging techniques have the potential to make surgical interventions safer and more effective; for these reasons, such techniques are quickly moving into the operating room. Here, we present a new approach that utilizes a technique not yet explored for intraoperative imaging: chemiluminescent imaging. This method employs a ruthenium-based chemiluminescent reporter along with a custom-built nebulizing system to produce ex vivo or in vivo images with high signal-to-noise ratios. The ruthenium-based reporter produces light following exposure to an aqueous oxidizing solution and re-reduction within the surrounding tissue. This method has allowed us to detect reporter concentrations as low as 6.9 pmol/cm

Indexed as

LuminescenceAnimalsDiagnostic ImagingFemaleLuminescent MeasurementsMaleMiceMice, NudeModels, AnimalMonitoring, Intraoperative

Identifiers

PMID28362395
PMCPMC5407651

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.