Evidence map›Paper›PMID 28362393›Full record

ArticleJournal of visualized experiments : JoVE2017

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation.

Ruiye Bi, Yi Fan, En Luo, Quan Yuan, Michael Mannstadt

Open access · bronzeAbstract readVideo-Audio Media
In one paragraph

Article in Journal of visualized experiments : JoVE, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Dicer-Mediated mTORC1 Signaling and Parathyroid Gland Integrity and Function.Journal of the American Society of Nephrology : JASN · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Ruiye BiEndocrine Unit, Massachusetts General Hospital, Harvard Medical School; West China School of Stomatology, Sichuan University.
Yi FanWest China School of Stomatology, Sichuan University; Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine.
En LuoWest China School of Stomatology, Sichuan University; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University.
Quan YuanWest China School of Stomatology, Sichuan University; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University.
Michael MannstadtEndocrine Unit, Massachusetts General Hospital, Harvard Medical School; mannstadt@mgh.harvard.edu.
State Key Laboratory of Oral DiseasesInstitute of Infection and Immunity · CAMassachusetts General Hospital · USSichuan University · CN

Funding

Mode of Action of GCM2, the Essential Parathyroid Transcription FactorR01DK100584 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MANNSTADT, MICHAEL · 2014 to 2018
$1.8M
NIDDK NIH HHS R01 DK100584
6 · The paper itself

Abstract

Hypoparathyroidism (HP) is a disorder characterized by low levels of PTH which lead to hypocalcemia, hyperphosphatemia, and low bone turnover. The most common cause of the disease is accidental removal of the parathyroid glands during thyroid surgery. Novel therapies for HP are needed, but testing them requires reliable animal models of acquired HP. Here, we demonstrate the generation of two mouse models of acquired HP. In the GFP-PTX model, mice with green fluorescent protein (GFP) expressed specifically in the parathyroids (PTHcre-mTmG) were created by crossing PTHcre

Indexed as

Disease Models, AnimalAnimalsCalciumDiphtheria ToxinFemaleHypoparathyroidismLuminescent AgentsMaleMiceMice, Inbred C57BLMice, TransgenicParathyroidectomyParathyroid GlandsParathyroid HormonePoisonsCalciumDiphtheria ToxinLuminescent AgentsParathyroid HormonePoisons

Identifiers

PMID28362393
PMCPMC5408591
OpenAlexW2599839270

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.