Evidence map›Paper›PMID 28362341›Full record

ReviewInternational journal of molecular sciences2017

The Role of MicroRNAs in Myocardial Infarction: From Molecular Mechanism to Clinical Application.

Teng Sun, Yan-Han Dong, Wei Du, Chun-Ying Shi, Kun Wang, Muhammad-Akram Tariq, Jian-Xun Wang, Pei-Feng Li

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 167 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. METTL14-mediated mActa pharmacologica Sinica · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Epigenetic analyses in forensic medicine: future and challenges.International journal of legal medicine · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Teng SunInstitute for Translational Medicine, Qingdao University, Qingdao 266021, China. tengsun@qdu.edu.cn.
Yan-Han DongInstitute for Translational Medicine, Qingdao University, Qingdao 266021, China. dongyanhande@163.com.
Wei DuInstitute for Translational Medicine, Qingdao University, Qingdao 266021, China. mtdw2015@126.com.
Chun-Ying ShiInstitute for Translational Medicine, Qingdao University, Qingdao 266021, China. schy1116@163.com.
Kun WangInstitute for Translational Medicine, Qingdao University, Qingdao 266021, China. wangk696@163.com.
Muhammad-Akram TariqInstitute for Translational Medicine, Qingdao University, Qingdao 266021, China. akram@soe.ucsc.edu.
Jian-Xun WangInstitute for Translational Medicine, Qingdao University, Qingdao 266021, China. wangjx@qdu.edu.cn.
Pei-Feng LiInstitute for Translational Medicine, Qingdao University, Qingdao 266021, China. peifli@qdu.edu.cn.
Qingdao University · CN

Funding

RPCI-UPCI Ovarian Cancer SPOREP50CA159981 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MOYSICH, KIRSTEN B. · 2013 to 2025
$19.6M
NCI NIH HHS P50 CA159981
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are a class of small single-stranded and highly conserved non-coding RNAs, which are closely linked to cardiac disorders such as myocardial infarction (MI), cardiomyocyte hypertrophy, and heart failure. A growing number of studies have demonstrated that miRNAs determine the fate of the heart by regulating cardiac cell death and regeneration after MI. A deep understanding of the pathophysiology of miRNA dependent regulatory pathways in these processes is required. The role of miRNAs as diagnostic, prognostic, and therapeutic targets also needs to be explored in order to utilize them in clinical settings. This review summarizes the role of miRNAs in myocardial infarction and focuses mainly on their influence on cardiomyocyte regeneration and cell death including apoptosis, necrosis, and autophagy. In addition, the targets of pro- and anti-MI miRNAs are comparatively described. In particular, the possibilities of miRNA-based diagnostic and therapeutic strategies for myocardial infarction are discussed in this review.

Indexed as

Gene Expression RegulationAnimalsHeart FailureHumansMicroRNAsModels, CardiovascularModels, GeneticMyocardial InfarctionMyocytes, CardiacTranslational Research, BiomedicalMicroRNAscardiomyocyte regenerationclinical applicationmicroRNAsmyocardial cell deathmyocardial infarction

Identifiers

PMID28362341
PMCPMC5412330
OpenAlexW2604185487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.