ReviewMolecules (Basel, Switzerland)2017
Chemical and Biological Properties of S-1-Propenyl-l-Cysteine in Aged Garlic Extract.
Review in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 95 citations in OpenAlex.
- Fermented garlic as a functional food strategy for malnutrition: microbial ecology, bioactive compounds, and clinical perspectives.Frontiers in nutrition · 2026Review
- Antihypertensive Plants Used by the Anak Dalam Tribe in Jambi, Indonesia: Ethnobotanical Insights and Pharmacological Potential as Alternatives to Conventional Medicine.Drug design, development and therapy · 2026Review
- Aged garlic extract major constituent S-1-propenyl-l-cysteine inhibits proinflammatory mRNA expression in bronchial epithelial IB3-1 cells exposed to the BNT162b2 vaccine.Experimental and therapeutic medicine · 2025Article
- Potential applications of components of aged garlic extract in mitigating pro-inflammatory gene expression linked to human diseases (Review).Experimental and therapeutic medicine · 2025Review
- Identification of S-1-propenyl-Food chemistry. Molecular sciences · 2025Article
- Effect of Temperature Conditions on the Physicochemical Quality of Aged Black Garlic.Foods (Basel, Switzerland) · 2024Article
- A Comparative Study of LC-MS and FIA-(ESI)MS for Quantitation ofFoods (Basel, Switzerland) · 2024Article
- Aged garlic extract preserves beta-cell functioning via modulation of nuclear factor kappa-B (NF-κB)/Toll-like receptor (TLR)-4 and sarco endoplasmic reticulum calcium ATPase (SERCA)/CaDiabetology & metabolic syndrome · 2024Article
- Ethnobotanical survey and scientific validation of liver-healing plants in northeastern Morocco.Frontiers in pharmacology · 2024Article
- Bioavailability of Organosulfur Compounds after the Ingestion of Black Garlic by Healthy Humans.Antioxidants (Basel, Switzerland) · 2023Article
- Turning Garlic into a Modern Crop: State of the Art and Perspectives.Plants (Basel, Switzerland) · 2023Review
- Garlic (Current issues in molecular biology · 2023Review
- The nutritional value, bioactive availability and functional properties of garlic and its related products during processing.Frontiers in nutrition · 2023Review
- Alterations in the Physicochemical Properties and Antioxidant Activity during Aging of Stored Raw Garlic.Foods (Basel, Switzerland) · 2022Article
- Assessment of standardization of domestic commercial black garlic extract forFood science and biotechnology · 2022Article
- S-1-Propenylcysteine promotes IL-10-induced M2c macrophage polarization through prolonged activation of IL-10R/STAT3 signaling.Scientific reports · 2021Article
- S-1-propenylcysteine improves TNF-α-induced vascular endothelial barrier dysfunction by suppressing the GEF-H1/RhoA/Rac pathway.Cell communication and signaling : CCS · 2021Article
- Ethnopharmacological Survey on Treatment of Hypertension by Traditional Healers in Bukavu City, DR Congo.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Antidiabetic Medicinal Plants Used in Democratic Republic of Congo: A Critical Review of Ethnopharmacology and Bioactivity Data.Frontiers in pharmacology · 2021Review
- Review: antimicrobial properties of allicin used alone or in combination with other medications.Folia microbiologica · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
S-1-Propenyl-l-cysteine (S1PC) is a stereoisomer of S-1-Propenyl-l-cysteine (SAC), an important sulfur-containing amino acid that plays a role for the beneficial pharmacological effects of aged garlic extract (AGE). The existence of S1PC in garlic preparations has been known since the 1960's. However, there was no report regarding the biological and/or pharmacological activity of S1PC until 2016. Recently, we performed a series of studies to examine the chemical, biological, pharmacological and pharmacokinetic properties of S1PC, and obtained some interesting results. S1PC existed only in trace amounts in raw garlic, but its concentration increased almost up to the level similar of SAC through aging process of AGE. S1PC showed immunomodulatory effects in vitro and in vivo, and reduced blood pressure in a hypertensive animal model. A pharmacokinetic study revealed that S1PC was readily absorbed after oral administration in rats and dogs with bioavailability of 88-100%. Additionally, S1PC had little inhibitory influence on human cytochrome P450 activities, even at a concentration of 1 mM. Based on these findings, S1PC was suggested to be another important, pharmacologically active and safe component of AGE similar to SAC. In this review, we highlight some results from recent studies on S1PC and discuss the potential medicinal value of S1PC.
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