Evidence map›Paper›PMID 28362321›Full record

ArticleInternational journal of molecular sciences2017

Early Assessment of Colorectal Cancer by Quantifying Circulating Tumor Cells in Peripheral Blood: ECT2 in Diagnosis of Colorectal Cancer.

Chih-Jung Chen, Wen-Wei Sung, Hung-Chang Chen, Yi-Jye Chern, Hui-Ting Hsu, Yueh-Min Lin, Shu-Hui Lin, Konan Peck, Kun-Tu Yeh

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chih-Jung ChenDepartment of Surgical Pathology, Changhua Christian Hospital, Changhua 8864, Taiwan. 132540@cch.org.tw.
Wen-Wei SungDepartment of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 88637, Taiwan. flutewayne@gmail.com.
Hung-Chang ChenDepartment of Colon and Rectal Surgery, Changhua Christian Hospital, Changhua, Taiwan. 54464@cch.org.tw.
Yi-Jye ChernInstitute of Biomedical Sciences, Academia Sinica, Taipei 8862, Taiwan. yijyechern@gmail.com.
Hui-Ting HsuDepartment of Surgical Pathology, Changhua Christian Hospital, Changhua 8864, Taiwan. javawomanfanny@gmail.com.
Yueh-Min LinDepartment of Surgical Pathology, Changhua Christian Hospital, Changhua 8864, Taiwan. 93668@cch.org.tw.
Shu-Hui LinDepartment of Surgical Pathology, Changhua Christian Hospital, Changhua 8864, Taiwan. 74630@cch.org.tw.
Konan PeckInstitute of Biomedical Sciences, Academia Sinica, Taipei 8862, Taiwan. freeman641016@yahoo.com.tw.
Kun-Tu YehDepartment of Surgical Pathology, Changhua Christian Hospital, Changhua 8864, Taiwan. 10159@cch.org.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating tumor cells (CTCs) in peripheral blood is an indication of poor prognosis for patients with different cancer types. However, most of the available technologies for detecting CTCs show low sensitivity and specificity. Therefore, we attempted to find an alternative marker for CTCs of colorectal cancer. We have directly extracted RNA from CTCs contained in 1.5 mL peripheral blood from 90 colorectal cancer patients and 151 healthy donors, and screened these samples for candidate marker genes by nested real-time quantitative polymerase chain reaction (PCR). From genes selected from a public database of microarray analyses, we successfully identified epithelial cell transforming sequence 2 oncogene (

Indexed as

Gene Expression Regulation, NeoplasticAdultAgedAged, 80 and overBiomarkers, TumorCarcinoembryonic AntigenColorectal NeoplasmsEarly Detection of CancerFemaleGene Expression ProfilingHumansMaleMiddle AgedNeoplastic Cells, CirculatingPrognosisProto-Oncogene ProteinsBiomarkers, TumorCarcinoembryonic AntigenECT2 protein, humanProto-Oncogene ProteinsbiomarkerCEAcirculating tumor cellcolorectal cancerECT2

Identifiers

PMID28362321
PMCPMC5412328

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.