ArticleeLife2017
Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line.
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Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers.
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114citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
What it found
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Who cites it
114 citing papers in PubMed, 169 citations in OpenAlex.
- Self-adjuvanting Ebola virus-like particles that incorporate a cellular interferon-inducing domain.Research square · 2026Article
- Loss of cellular RNA homeostasis contributes to MDA5 activation during virus infection.Nature immunology · 2026Article
- Article
- Targeting ADAR1 in Cancer: Biology, Therapeutic Strategies, Challenges, and Limitations.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Sensing of double-stranded RNA in human cells: molecular mechanisms and cellular consequences.Biochemical Society transactions · 2026Review
- ADAR1 regulates dsRNA formation in nuclear and mitochondrial transcripts through editing-dependent and -independent mechanisms.Cell reports · 2026Article
- TSniffer: unbiased de novo identification of RNA editing sites and quantification of editing activity in RNA-seq data.Genome biology · 2026Article
- Nonsense-mediated decay controls a negative feedback loop in innate immune sensing.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The OAS-RNase L pathway: Insights from experiments of nature.Science immunology · 2026Review
- ADAR1: a central regulator of dsRNA sensing in host-virus interactions.Frontiers in immunology · 2026Review
- The context-dependent role of the dsRNA response in linking A-to-I editing and ADAR to normal hematopoiesis and leukemia.Frontiers in cell and developmental biology · 2026Review
- Activated oligoadenylate synthetase-ribonuclease L pathway promotes endothelial pyroptosis and impairs diabetic wound healing via thioredoxin-interacting protein mMolecular biomedicine · 2025Article
- A hepatitis B virus RNA-sensing and RNA-editing-dependent reporter system.Journal of virology · 2025Article
- SARS-CoV-2 Nsp15 endoribonuclease subverts host defenses to enhance viral fitness in lung cells.Journal of virology · 2025Article
- Article
- Effective recognition of double-stranded RNA does not require activation of cellular inflammation.Science advances · 2025Article
- ADAR1 p150 prevents HSV-1 from triggering PKR/eIF2α-mediated translational arrest and is required for efficient viral replication.PLoS pathogens · 2025Article
- Human coronaviruses: activation and antagonism of innate immune responses.Microbiology and molecular biology reviews : MMBR · 2025Review
- A Wonderful Journey: The Diverse Roles of Adenosine Deaminase Action on RNA 1 (ADAR1) in Central Nervous System Diseases.CNS neuroscience & therapeutics · 2025Review
- ADAR1: from basic mechanisms to inhibitors.Trends in cell biology · 2025Review
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Yize LiDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0003-1721-741X
Shuvojit BanerjeeDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
Stephen A GoldsteinDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Beihua DongDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
Christina GaughanDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
Sneha RathDepartment of Molecular Biology, Princeton University, Princeton, United States.
Jesse DonovanDepartment of Molecular Biology, Princeton University, Princeton, United States.
Alexei KorennykhDepartment of Molecular Biology, Princeton University, Princeton, United States.
Robert H SilvermanDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
Susan R WeissDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0002-8155-4528
Cleveland Clinic Lerner College of Medicine · USPrinceton University · USUniversity of Pennsylvania · US
Funding
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007388 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 1985 to 2022
$27.4MControl of Viral Pathogenesis by Regulation of 2-5A LevelsR01AI104887 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SILVERMAN, ROBERT H., WEISS, SUSAN R · 2013 to 2023
$7.6MTRAINING IN VIROLOGYT32AI007324 · NIAID · WISTAR INSTITUTE · PI Paul Bates, Matthew D. Weitzman · 1989 to 2026
$6.8MREGULATION OF 2-5A-DEPENDENT RNASE LEVELS OF INTERFERONR01CA044059 · NCI · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI SILVERMAN, ROBERT H. · 1986 to 2015
$6.1MStructure and Function of Kinase Family Receptors Regulating TranslationR01GM110161 · NIGMS · PRINCETON UNIVERSITY · PI KORENNYKH, ALEXEI · 2014 to 2022
$2.5MMurine coronavirus neurovirulence: role of type I interferon responseR01NS081008 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI WEISS, SUSAN R · 2012 to 2016
$1.7MMolecular Determinants of Mitochondrial Genome Abundance and IntegrityK00CA212468 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI RATH, SNEHA PRAKASH · 2019 to 2022
$385kBeyond infection: Innate immune receptors as an emerging brake on metastasisF99CA212468 · NCI · PRINCETON UNIVERSITY · PI RATH, SNEHA PRAKASH · 2016 to 2017
$89kNCI NIH HHS F99 CA212468NCI NIH HHS K00 CA212468NCI NIH HHS R01 CA044059NIAID NIH HHS R01 AI104887NIAID NIH HHS T32 AI007324NIGMS NIH HHS R01 GM110161NIGMS NIH HHS T32 GM007388NINDS NIH HHS R01 NS081008
Abstract
ADAR1 isoforms are adenosine deaminases that edit and destabilize double-stranded RNA reducing its immunostimulatory activities. Mutation of
Indexed as
Cell DeathAdaptor Proteins, Signal TransducingAdenosine DeaminaseCell Line, TumorEndoribonucleasesEpithelial CellsHumansInterferon-Induced Helicase, IFIH1RNA-Binding Proteins2-5A-dependent ribonucleaseAdaptor Proteins, Signal TransducingADAR protein, humanAdenosine DeaminaseEndoribonucleasesIFIH1 protein, humanInterferon-Induced Helicase, IFIH1MAVS protein, humanRNA-Binding Proteinsadenosine deaminasecell deathhumanimmunologyinfectious diseaseinterferonopathaymicrobiologyphosphodiesteraseribonuclease L
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.