ArticleScientific reports2017
Identification of two p53 isoforms from Litopenaeus vannamei and their interaction with NF-κB to induce distinct immune response.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 27 citations in OpenAlex.
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- Marine DiatomAquaculture nutrition · 2025Article
- Modulation of the unfolded protein response by white spot syndrome virus via wsv406 targeting BiP to facilitate viral replication.Virologica Sinica · 2024Article
- A simple sequence repeats marker of disease resistance in shrimpFrontiers in genetics · 2023Article
- p53 Ubiquitination Comediated by HUWE1 and TRAF6 Contributes to White Spot Syndrome Virus Infection in Crustacean.Journal of virology · 2022Article
- Stimulator of interferon genes defends against bacterial infectionFrontiers in immunology · 2022Article
- Adaptive homeostasis and the p53 isoform network.EMBO reports · 2021Review
- BigPEN, an antimicrobial peptide of penaeidin family from shrimpFish and shellfish immunology reports · 2021Article
- Penaeidins restrict white spot syndrome virus infection by antagonizing the envelope proteins to block viral entry.Emerging microbes & infections · 2020Article
- TNF-Receptor-Associated Factor 3 inFrontiers in immunology · 2020Article
- The Two NF-κB Pathways Regulating Bacterial and WSSV Infection of Shrimp.Frontiers in immunology · 2019Review
- RNAi screening identifies a new Toll from shrimp Litopenaeus vannamei that restricts WSSV infection through activating Dorsal to induce antimicrobial peptides.PLoS pathogens · 2018Article
- Putting p53 in Context.Cell · 2017Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
p53 is a transcription factor with capability of regulating diverse NF-κB dependent biological progresses such as inflammation and host defense, but the actual mechanism remains unrevealed. Herein, we firstly identified two novel alternatively spliced isoforms of p53 from Litopenaeus vannamei (LvΔNp53 and the full-length of p53, LvFLp53). We then established that the two p53 isoforms exerted opposite effects on regulating NF-κB induced antimicrobial peptides (AMPs) and white spot syndrome virus (WSSV) immediate-early (IE) genes expression, suggesting there could be a crosstalk between p53 and NF-κB pathways. Of note, both of the two p53 isoforms could interact directly with LvDorsal, a shrimp homolog of NF-κB. In addition, the activation of NF-κB mediated by LvDorsal was provoked by LvΔNp53 but suppressed by LvFLp53, and the increased NF-κB activity conferred by LvΔNp53 can be attenuated by LvFLp53. Furthermore, silencing of LvFLp53 in shrimp caused higher mortalities and virus loads under WSSV infection, whereas LvΔNp53-knockdown shrimps exhibited an opposed RNAi phenotype. Taken together, these findings present here provided some novel insight into different roles of shrimp p53 isoforms in immune response, and some information for us to understand the regulatory crosstalk between p53 pathway and NF-κB pathway in invertebrates.
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