ArticleScientific reports2017
Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 97 citations in OpenAlex.
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- MAEST: accurately spatial domain detection in spatial transcriptomics with graph masked autoencoder.Briefings in bioinformatics · 2025Article
- A single-cell mass cytometry-based atlas of the developing mouse brain.Nature neuroscience · 2025Article
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- SETDB1 regulates short interspersed nuclear elements and chromatin loop organization in mouse neural precursor cells.Genome biology · 2024Article
- Deletion of Slc9a1 in Cx3cr1Journal of neuroinflammation · 2024Article
- Molecular organization of neuronal cell types and neuromodulatory systems in the zebrafish telencephalon.Current biology : CB · 2024Article
- Aging restricts the initial neural patterning potential of developing neural stem and progenitor cells in the adult brain.Frontiers in aging neuroscience · 2024Article
- Psychiatric risk gene Transcription Factor 4 (TCF4) regulates the density and connectivity of distinct inhibitory interneuron subtypes.Molecular psychiatry · 2023Article
- Spatial transcriptomics map of the embryonic mouse brain - a tool to explore neurogenesis.Biology open · 2023Article
- Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy.Cell stem cell · 2023Article
- MuDCoD: multi-subject community detection in personalized dynamic gene networks from single-cell RNA sequencing.Bioinformatics (Oxford, England) · 2023Article
- DOT1L deletion impairs the development of cortical parvalbumin-expressing interneurons.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Pharmacological Inhibition of NHE1 Protein Increases White Matter Resilience and Neurofunctional Recovery after Ischemic Stroke.International journal of molecular sciences · 2023Article
- Cell and circuit complexity of the external globus pallidus.Nature neuroscience · 2023Review
- A single-cell trajectory atlas of striatal development.Scientific reports · 2023Article
- Debiased personalized gene coexpression networks for population-scale scRNA-seq data.Genome research · 2023Article
- Single-Cell Transcriptomics Reveals Conserved Regulatory Networks in Human and Mouse Interneuron Development.International journal of molecular sciences · 2023Article
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Authors and funding
8 authors at 1 institution in 1 country.
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Abstract
Many subtypes of cortical interneurons (CINs) are found in adult mouse cortices, but the mechanism generating their diversity remains elusive. We performed single-cell RNA sequencing on the mouse embryonic medial ganglionic eminence (MGE), the major birthplace for CINs, and on MGE-like cells differentiated from embryonic stem cells. Two distinct cell types were identified as proliferating neural progenitors and immature neurons, both of which comprised sub-populations. Although lineage development of MGE progenitors was reconstructed and immature neurons were characterized as GABAergic, cells that might correspond to precursors of different CINs were not identified. A few non-neuronal cell types were detected, including microglia. In vitro MGE-like cells resembled bona fide MGE cells but expressed lower levels of Foxg1 and Epha4. Together, our data provide detailed understanding of the embryonic MGE developmental program and suggest how CINs are specified.
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