Evidence map›Paper›PMID 28361874›Full record

ArticleNature communications2017

IL-15 sustains IL-7R-independent ILC2 and ILC3 development.

Michelle L Robinette, Jennifer K Bando, Wilbur Song, Tyler K Ulland, Susan Gilfillan, Marco Colonna

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 109 citations in OpenAlex.

  1. Article
  2. IDH1 Mutant Glioma Favors Group 3 Innate Lymphoid Cells and Is Resistant to Immune Checkpoint Expression.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. PLZF-expressing CD4Cell communication and signaling : CCS · 2025
    Article
  7. Review
  8. Article
  9. Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory axis.bioRxiv : the preprint server for biology · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. ILC3: a case of conflicted identity.Frontiers in immunology · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Michelle L RobinetteDepartment of Pathology &Immunology, Washington University School of Medicine, 509 S. Euclid Ave Box 8118, St Louis, Missouri 63110, USA.ORCID 0000-0003-0965-5225
Jennifer K BandoDepartment of Pathology &Immunology, Washington University School of Medicine, 509 S. Euclid Ave Box 8118, St Louis, Missouri 63110, USA.
Wilbur SongDepartment of Pathology &Immunology, Washington University School of Medicine, 509 S. Euclid Ave Box 8118, St Louis, Missouri 63110, USA.
Tyler K UllandDepartment of Pathology &Immunology, Washington University School of Medicine, 509 S. Euclid Ave Box 8118, St Louis, Missouri 63110, USA.
Susan GilfillanDepartment of Pathology &Immunology, Washington University School of Medicine, 509 S. Euclid Ave Box 8118, St Louis, Missouri 63110, USA.
Marco ColonnaDepartment of Pathology &Immunology, Washington University School of Medicine, 509 S. Euclid Ave Box 8118, St Louis, Missouri 63110, USA.
Washington University in St. Louis · US

Funding

TRAINING IN THE IMMUNOBIOLOGY AND MOLECULAR CELL BIOLOGY OF CANCERT32CA009547 · NCI · WASHINGTON UNIVERSITY · PI ROBERT DAVID SCHREIBER · 1986 to 2026
$12.1M
Mucosal Immune Defense Mechanisms of the Urinary BladderU01AI095542 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, HULTGREN, SCOTT J. · 2011 to 2020
$9.8M
TREM2 IN MICROGLIA BIOLOGY AND ALZHEIMER'S DISEASERF1AG051485 · NIA · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2015 to 2021
$3.5M
The role of TGFbeta in development and function of salivary gland innate lymphoid cellsR01DE025884 · NIDCR · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, WEISMAN, GARY ANDREW · 2017 to 2021
$3.5M
Mechanisms of ILC3 Development and Plasticity in the Gastrointestinal Tract.F30DK107053 · NIDDK · WASHINGTON UNIVERSITY · PI ROBINETTE, MICHELLE LAUREN · 2015 to 2017
$109k
NCI NIH HHS T32 CA009547NIAID NIH HHS U01 AI095542NIA NIH HHS RF1 AG051485NIDCR NIH HHS R01 DE025884NIDDK NIH HHS F30 DK107053
6 · The paper itself

Abstract

The signals that maintain tissue-resident innate lymphoid cells (ILC) in different microenvironments are incompletely understood. Here we show that IL-7 receptor (IL-7R) is not strictly required for the development of any ILC subset, as residual cells persist in the small intestinal lamina propria (siLP) of adult and neonatal Il7ra

Indexed as

AnimalsFemaleImmunity, InnateInterleukin-15Intestine, SmallKiller Cells, NaturalLymphocytesLymphocyte SubsetsMaleMiceMice, Inbred C57BLMice, KnockoutMucous MembraneReceptors, Interleukin-7Signal TransductionInterleukin-15Receptors, Interleukin-7

Identifiers

PMID28361874
PMCPMC5380969
OpenAlexW2603591537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.