ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017
Associations Between Daily Affective Instability and Connectomics in Functional Subnetworks in Remitted Patients with Recurrent Major Depressive Disorder.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Better together: A systematic review of studies combining magnetic resonance imaging with ecological momentary assessment.Social neuroscience · 2024Pooled it
- Remission is insufficient: predictors and mechanistic models of recurrence in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Complex Emotion Dynamics Contribute to the Prediction of Depression: A Machine Learning and Time Series Feature Extraction Approach.Affective science · 2024Article
- Assessing depression recurrence, cognitive burden, and neurobiological homeostasis in late life: Design and rationale of the REMBRANDT Study.Journal of mood and anxiety disorders · 2024Article
- Depression recurrence is accompanied by longer periods in default mode and more frequent attentional and reward processing dynamic brain-states during resting-state activity.Human brain mapping · 2023Article
- Trait- and state-like co-activation pattern dynamics in current and remitted major depressive disorder.Journal of affective disorders · 2023Article
- Inflammation-driven brain and gut barrier dysfunction in stress and mood disorders.The European journal of neuroscience · 2022Review
- Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome.Translational psychiatry · 2021Review
- Affect fluctuations examined with ecological momentary assessment in patients with current or remitted depression and anxiety disorders.Psychological medicine · 2021Article
- Network-level functional topological changes after mindfulness-based cognitive therapy in mood dysregulated adolescents at familial risk for bipolar disorder: a pilot study.BMC psychiatry · 2021Article
- Persistent Intrinsic Functional Network Connectivity Alterations in Middle-Aged and Older Women With Remitted Depression.Frontiers in psychiatry · 2020Article
- Disruption of Neural Homeostasis as a Model of Relapse and Recurrence in Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019Review
- Impaired reward-related learning signals in remitted unmedicated patients with recurrent depression.Brain : a journal of neurology · 2019Article
- Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder.Human brain mapping · 2019Article
- Resting-state functional connectivity and inflexibility of daily emotions in major depression.Journal of affective disorders · 2019Article
- Emotional Biases and Recurrence in Major Depressive Disorder. Results of 2.5 Years Follow-Up of Drug-Free Cohort Vulnerable for Recurrence.Frontiers in psychiatry · 2019Article
- A pilot resting-state functional connectivity study of the kynurenine pathway in adolescents with depression and healthy controls.Journal of affective disorders · 2018Article
- Different Aspects of the Neural Response to Socio-Emotional Events Are Related to Instability and Inertia of Emotional Experience in Daily Life: An fMRI-ESM Study.Frontiers in human neuroscience · 2018Article
- From State-to-Trait Meditation: Reconfiguration of Central Executive and Default Mode Networks.eNeuroArticle
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Remitted patients with major depressive disorder (rMDD) often report more fluctuations in mood as residual symptomatology. It is unclear how this affective instability is associated with information processing related to the default mode (DMS), salience/reward (SRS), and frontoparietal (FPS) subnetworks in rMDD patients at high risk of recurrence (rrMDD). Sixty-two unipolar, drug-free rrMDD patients (⩾2 MDD episodes) and 41 healthy controls (HCs) were recruited. We used experience sampling methodology to monitor mood/cognitions (10 times a day for 6 days) and calculated affective instability using the mean adjusted absolute successive difference. Subsequently, we collected resting-state functional magnetic resonance imaging data and performed graph theory to obtain network metrics of integration within (local efficiency) the DMS, SRS, and FPS, and between (participation coefficient) these subnetworks and others. In rrMDD patients compared with HCs, we found that affective instability was increased in most negative mood/cognition variables and that the DMS had less connections with other subnetworks. Furthermore, we found that rrMDD patients, who showed more instability in feeling down and irritated, had less connections between the SRS and other subnetworks and higher local efficiency coefficients in the FPS, respectively. In conclusion, rrMDD patients, compared with HCs, are less stable in their negative mood and these dynamics are related to differences in information processing within- and between-specific functional subnetworks. These results are a first step to gain a better understanding of how mood fluctuations in real life are represented in the brain and provide insights into the vulnerability profile of MDD.
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