ReviewUrolithiasis2017
Pathogenesis of calcium oxalate urinary stone disease: species comparison of humans, dogs, and cats.
Review in Urolithiasis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 57 citations in OpenAlex.
- Trial
- Animal Models of Hyperoxaluria and Their Relevance for Fundamental Research and Clinical Practice.International journal of molecular sciences · 2026Review
- Animal models for calcium oxalate kidney stone research.Zoological research · 2026Review
- Neutrophil Extracellular Traps Promote Urolithiasis Formation in Dogs: A Preliminary Study.Animals : an open access journal from MDPI · 2026Article
- Animal Tissue Mineralization: An Overview of Disease Processes, Comparative Pathology, and Diagnostic Approaches.Biomolecules · 2026Review
- A placebo-controlled study of an herbal compound used for management of lower urinary tract disease in healthy cats.Frontiers in veterinary science · 2026Article
- A 5-year retrospective epidemiological and compositional study of canine and feline uroliths in Tehran, Iran (2019 - 2024).Veterinary research forum : an international quarterly journal · 2026Article
- Effects of calcium oxalate crystals on neutrophil cellular proteome and functions: implications for nephrolithiasis.Cell communication and signaling : CCS · 2025Article
- Oxidative stress, inflammation and kidney stones.Urolithiasis · 2025Article
- Organoid models of ovarian cancer: resolving immune mechanisms of metabolic reprogramming and drug resistance.Frontiers in immunology · 2025Review
- Long-Term Sodium Deficiency Reduces Sodium Excretion but Impairs Renal Function and Increases Stone Formation in Hyperoxaluric Calcium Oxalate Rats.International journal of molecular sciences · 2024Article
- Different Degrees of Sulfated Laminaria Polysaccharides Recovered Damaged HK-2 Cells and Inhibited Adhesion of Nano-COM and Nano-COD Crystals.Bioinorganic chemistry and applications · 2024Article
- A urinary proteomic study in hypercalciuric dogs with and without calcium oxalate urolithiasis.Veterinary world · 2022Article
- Alendronate treatment in cats with persistent ionized hypercalcemia: A retrospective cohort study of 20 cases.Journal of veterinary internal medicine · 2022Article
- Metabolomic changes in cats with renal disease and calcium oxalate uroliths.Metabolomics : Official journal of the Metabolomic Society · 2022Article
- Analysis of potential risk factors associated with urolithiasis.Central European journal of public health · 2022Article
- Recent Progress on the Salt Tolerance Mechanisms and Application of Tamarisk.International journal of molecular sciences · 2022Review
- Association between visceral adiposity index and kidney stones in American adults: A cross-sectional analysis of NHANES 2007-2018.Frontiers in nutrition · 2022Article
- Subcutaneous ureteral bypass device placement with intraoperative ultrasound guidance, with or without microsurgical ureterotomy, in 24 cats.Journal of feline medicine and surgery · 2021Article
- Transporters and tubule crystals in the insect Malpighian tubule.Current opinion in insect science · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Idiopathic calcium oxalate nephrolithiasis is a highly recurrent disease that is increasing in prevalence. Decades of research have not identified effective methods to consistently prevent the formation of nephroliths or induce medical dissolution. Idiopathic calcium oxalate nephroliths form in association with renal papillary subepithelial calcium phosphate deposits called Randall's plaques (RPs). Rodent models are commonly used to experimentally induce calcium oxalate crystal and stone formation, but a rodent model that conclusively forms RPs has not been identified. Both dogs and cats form calcium oxalate uroliths that can be recurrent, but the etiopathologic mechanisms of stone formation, especially renal pathologic findings, are a relatively unexploited area of study. A large animal model that shares a similar environment to humans, along with a shorter lifespan and thus shorter time to recurrence, might provide an excellent means to study preventative and therapeutic measures, along with enhancing the concepts of the one health initiative. This review article summarizes and compares important known features of idiopathic calcium oxalate stone disease in humans, dogs, and cats, and emphasizes important knowledge gaps and areas for future study in the quest to discover a naturally occurring animal model of idiopathic calcium oxalate stone disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.