Evidence map›Paper›PMID 28361386›Full record

ReviewCurrent allergy and asthma reports2017

Human Immune Monitoring Techniques during Food Allergen Immunotherapy.

Blake J Rust, Erik Wambre

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Current allergy and asthma reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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  7. Immune mechanisms of oral immunotherapy.The Journal of allergy and clinical immunology · 2018
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution.

Blake J RustDepartment of Translational Immunology, Benaroya Research Institute, Seattle, WA, USA.
Erik WambreDepartment of Translational Immunology, Benaroya Research Institute, Seattle, WA, USA. ewambre@benaroyaresearch.org.
Benaroya Research Institute

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewEncouraging results from recent food allergen immunotherapy clinical trials indicate that the immune system plays an essential role in peripheral tolerance to food allergen. Thus, the monitoring of changes in immune responses and their possible correlation with clinical outcome in allergic patients receiving immunotherapies could theoretically serve as surrogate markers and be harnessed as rationale for food allergen immunotherapy development. RECENT

findingsA shift towards antigen specificity in recent assays has provided a solid foundation for the elucidation of cellular mechanisms involved in food allergen immunotherapy as well as the tracking of allergen-specific immune cells. In this review, we overview the current challenges and technologies used in immune monitoring during immunotherapy in allergic patients with a focus on cell-mediated immunity. We also discuss critical steps involved in some of the cellular immune assays utilized in clinical trials.

Indexed as

AllergensBasophilsClinical Trials as TopicDesensitization, ImmunologicFood HypersensitivityHumansImmune ToleranceImmunity, CellularImmunotherapyMonitoring, ImmunologicT-LymphocytesAllergensAntigen-specificBasophil activationEffector T cellsFood allergyImmunotherapyRegulatory T cells

Identifiers

PMID28361386
OpenAlexW2598696339

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.