ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2017
Functional disruption of peroxiredoxin by bismuth antiulcer drugs attenuates Helicobacter pylori survival.
Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 19 citations in OpenAlex.
- Hydrogen Peroxide-Mediated Oxygen Enrichment Eradicates Helicobacter pyloriAntimicrobial agents and chemotherapy · 2020Article
- Multi-omics and temporal dynamics profiling reveal disruption of central metabolism inChemical science · 2018Article
- Cytotoxicity of biologically synthesised bismuth nanoparticles against HT-29 cell line.IET nanobiotechnology · 2018Article
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6 authors at 1 institution in 1 country.
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Abstract
Bismuth drugs have been used clinically to treat infections from Helicobacter pylori, a pathogen that is strongly related to gastrointestinal diseases even stomach cancer. Despite extensive studies, the mechanisms of action of bismuth drugs are not fully understood. Alkyl hydroperoxide reductase subunit C (AhpC) is the most abundant 2-cysteine peroxiredoxin, crucial for H. pylori survival in the host by defense of oxidative stress. Herein we show that a Bi(III) antiulcer drug (CBS) binds to the highly conserved cysteine residues (Cys49 and Cys169) with a dissociation constant (K
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