ReviewCurrent rheumatology reports2017
Chronic Recurrent Multifocal Osteomyelitis and Related Diseases-Update on Pathogenesis.
Review in Current rheumatology reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- The 2021 EULAR/American College of Rheumatology Points to Consider for Diagnosis, Management and Monitoring of the Interleukin-1 Mediated Autoinflammatory Diseases: Cryopyrin-Associated Periodic Syndromes, Tumour Necrosis Factor Receptor-Associated Periodic Syndrome, Mevalonate Kinase Deficiency, and Deficiency of the Interleukin-1 Receptor Antagonist.Arthritis & rheumatology (Hoboken, N.J.) · 2022Pooled it
- Chronic Nonbacterial Osteomyelitis in Latvia from 2014 to 2025: Case Series.Medicina (Kaunas, Lithuania) · 2026Article
- Ustekinumab as a novel treatment of chronic nonbacterial osteomyelitis: a case report.AME case reports · 2026Article
- Diagnostic value of neutrophil to lymphocyte ratio and serum biomarkers in chronic osteomyelitis.Scientific reports · 2025Article
- Pamidronate-Induced Clinical Remission in Chronic Non-bacterial Osteomyelitis Is Associated with Reduced Vγ9Vδ2 T-Cell Receptor Expression.European journal of immunology · 2025Article
- A child with Chronic Nonbacterial Osteomyelitis and celiac disease: accidental association or two different aspects of the same condition?Italian journal of pediatrics · 2025Article
- IL-1 blocking experience in a case with Majeed syndrome diagnosed in adulthood.Zeitschrift fur Rheumatologie · 2024Article
- Sterile osteomyelitis: a cardinal sign of autoinflammation.Reumatologia · 2024Review
- Chronic Nonbacterial Osteomyelitis in Inflammatory Bowel Disease.Life (Basel, Switzerland) · 2023Review
- FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma.Open medicine (Warsaw, Poland) · 2023Article
- IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting.Nature reviews. Rheumatology · 2022Review
- Application of Mesoporous Silica Nanoparticle-Chitosan-Loaded BMP-2 in the Repair of Bone Defect in Chronic Osteomyelitis.Journal of immunology research · 2022Article
- Nano Sized Hydroxyapatite-Polylactic Acid-Vancomycin in Alleviation of Chronic Osteomyelitis.Drug design, development and therapy · 2022Article
- Chronic recurrent multifocal osteomyelitis. A narrative and pictorial review.Frontiers in immunology · 2022Review
- Chronic Recurrent Multifocal Osteomyelitis of the Hand: A Rare Pediatric Condition.Hand (New York, N.Y.) · 2021Review
- Majeed Syndrome: A Review of the Clinical, Genetic and Immunologic Features.Biomolecules · 2021Review
- Role of the F-BAR Family Member PSTPIP2 in Autoinflammatory Diseases.Frontiers in immunology · 2021Review
- Genomic Expression Profiling and Bioinformatics Analysis of Chronic Recurrent Multifocal Osteomyelitis.BioMed research international · 2021Article
- New Insights into Adult and Paediatric Chronic Non-bacterial Osteomyelitis CNO.Current rheumatology reports · 2020Review
- Staphylococcus aureus Osteomyelitis: Bone, Bugs, and Surgery.Infection and immunity · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewWe focus on recent advances in the understanding of the genetic, molecular, immunologic, and environmental factors implicated in the pathogenesis of autoinflammatory bone diseases including the syndromic and non-syndromic forms of chronic recurrent multifocal osteomyelitis (CRMO). RECENT
findingsEvidence implicating the IL-1 pathway in the pathogenesis of the Mendelian forms of CRMO is growing. LIPIN2 can regulate the NLRP3 inflammasome by affecting P2X7 receptor activation, and intracellular cholesterol can modulate P2X7R currents. Work in a mouse model of CRMO demonstrates that dietary manipulation can alter the microbiome and protect these mice from the development of sterile osteomyelitis in vivo. Although the genetic and immunologic basis of non-syndromic CRMO remains only partially understood, the IL-1 pathway is central to the pathogenesis in the syndromic autoinflammatory bone disorders. Recent work implicates lipids and the microbiome in sterile osteomyelitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.