Evidence map›Paper›PMID 28361294›Full record

ArticleBiomechanics and modeling in mechanobiology2017

Image-based multiscale mechanical modeling shows the importance of structural heterogeneity in the human lumbar facet capsular ligament.

Vahhab Zarei, Chao J Liu, Amy A Claeson, Taner Akkin, Victor H Barocas

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomechanics and modeling in mechanobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 29 citations in OpenAlex.

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  17. The role of the facet capsular ligament in providing spinal stability.Computer methods in biomechanics and biomedical engineering · 2018
    Article
  18. Multi-resolution geometric modeling of the mitral heart valve leaflets.Biomechanics and modeling in mechanobiology · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Vahhab ZareiDepartments of Mechanical Engineering, University of Minnesota-Twin Cities, Minneapolis, MN, USA.
Chao J LiuDepartments of Biomedical Engineering, Universityof Minnesota-Twin Cities, Minneapolis, MN, USA.
Amy A ClaesonDepartments of Biomedical Engineering, Universityof Minnesota-Twin Cities, Minneapolis, MN, USA.
Taner AkkinDepartments of Biomedical Engineering, Universityof Minnesota-Twin Cities, Minneapolis, MN, USA.
Victor H BarocasDepartments of Biomedical Engineering, Universityof Minnesota-Twin Cities, Minneapolis, MN, USA. baroc001@umn.edu.
Twin Cities Orthopedics · USUniversity of Minnesota · US

Funding

Multiscale Modeling of Facet Capsule MechanobiologyU01EB016638 · NIBIB · UNIVERSITY OF MINNESOTA · PI BAROCAS, VICTOR H, WINKELSTEIN, BETH A · 2013 to 2017
$2.4M
NIBIB NIH HHS U01 EB016638
6 · The paper itself

Abstract

The lumbar facet capsular ligament (FCL) primarily consists of aligned type I collagen fibers that are mainly oriented across the joint. The aim of this study was to characterize and incorporate in-plane local fiber structure into a multiscale finite element model to predict the mechanical response of the FCL during in vitro mechanical tests, accounting for the heterogeneity in different scales. Characterization was accomplished by using entire-domain polarization-sensitive optical coherence tomography to measure the fiber structure of cadaveric lumbar FCLs ([Formula: see text]). Our imaging results showed that fibers in the lumbar FCL have a highly heterogeneous distribution and are neither isotropic nor completely aligned. The averaged fiber orientation was [Formula: see text] ([Formula: see text] in the inferior region and [Formula: see text] in the middle and superior regions), with respect to lateral-medial direction (superior-medial to inferior-lateral). These imaging data were used to construct heterogeneous structural models, which were then used to predict experimental gross force-strain behavior and the strain distribution during equibiaxial and strip biaxial tests. For equibiaxial loading, the structural model fit the experimental data well but underestimated the lateral-medial forces by [Formula: see text]16% on average. We also observed pronounced heterogeneity in the strain field, with stretch ratios for different elements along the lateral-medial axis of sample typically ranging from about 0.95 to 1.25 during a 12% strip biaxial stretch in the lateral-medial direction. This work highlights the multiscale structural and mechanical heterogeneity of the lumbar FCL, which is significant both in terms of injury prediction and microstructural constituents' (e.g., neurons) behavior.

Indexed as

Models, BiologicalBiomechanical PhenomenaCadaverCollagen Type IHumansLigaments, ArticularStress, MechanicalTomography, Optical CoherenceZygapophyseal JointCollagen Type ICollagen fibersFacet capsular ligamentFiber imagingFiber structureMultiscale modelingSpineStructural heterogeneity

Identifiers

PMID28361294
PMCPMC5704991
OpenAlexW2603262544

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.