Trial reportClinical oral investigations2018
Reducing dentine hypersensitivity with nano-hydroxyapatite toothpaste: a double-blind randomized controlled trial.
Trial report in Clinical oral investigations, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- The effect of photobiomodulation using low-level laser therapy on tooth sensitivity after dental bleaching: a systematic review.Lasers in medical science · 2022Pooled it
- Effectiveness for dentin hypersensitivity treatment of non-carious cervical lesions: a meta-analysis.Clinical oral investigations · 2018Pooled it
- Clinical effectiveness of theobromine, Remin Pro, and their combination in managing dentin hypersensitivity: a randomized clinical trial.BMC oral health · 2026Trial
- Synergistic efficacy of a biomimetic hydroxyapatite-citrate complex for dentin hypersensitivity: an in vitro and clinical study.BMC oral health · 2026Trial
- Tooth sensitivity and whitening effect of an in-office bleaching gel containing 2% sodium fluoride: a randomized triple-blind clinical trial.Clinical oral investigations · 2025Trial
- The clinical and microbiological efficacy of a zinc-citrate/hydroxyapatite/potassium-citrate containing toothpaste: a double-blind randomized controlled clinical trial.Clinical oral investigations · 2024Trial
- A randomized clinical trial for comparing the efficacy of desensitizing toothpastes on the relief of dentin hypersensitivity.Scientific reports · 2023Trial
- Bonding properties of mild universal adhesives to dentin pretreated with hydroxyapatite-based desensitizing agents.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2022Trial
- Efficacy of a Toothpaste Based on Microcrystalline Hydroxyapatite on Children with Hypersensitivity Caused by MIH: A Randomised Controlled Trial.Oral health & preventive dentistry · 2021Trial
- Efficiency of desensitizing materials in xerostomic patients with head and neck cancer: a comparative clinical study.Clinical oral investigations · 2020Trial
- Optimization of Cytokinesis-Block Micronucleus Assay for Clastogenic Risk Assessment of Silver-Containing Nanomaterials.Nanomaterials (Basel, Switzerland) · 2026Article
- Comparative Effects of Experimental Bioactive Glasses on Dentin Permeability and Tubule Occlusion In Vitro.Journal of functional biomaterials · 2026Article
- Comparative evaluation of nano-hydroxyapatite dentifrice, diode laser alone and combined for dentin hypersensitivity: A randomized clinical trial.Bioinformation · 2026Article
- Short-term effectiveness of three agents for dentin hypersensitivity treatment: A randomized clinical trial.Bioinformation · 2026Article
- Antibacterial and anti-biofilm effects of postbiotic mediator derived fromJournal of oral microbiology · 2026Article
- Energy Dispersive Spectroscopy of Open Dentinal Tubules on Application of Nanocrystalline Hydroxyapatite: An In Vitro Study.F1000Research · 2026Article
- Directed Self-Assembly of Magnetic Bioceramic Deep Inside Dentinal Tubules May Alleviate Dental Hypersensitivity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Advances of Hydroxyapatite Nanoparticles in Dental Implant Applications.International dental journal · 2025Review
- Efficiency of glass ionomer sealant application in reducing hypersensitivity in MIH-molars in schoolchildren immediately and after 12 weeks.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Article
- Application of Nanohydroxyapatite in Medicine-A Narrative Review.Molecules (Basel, Switzerland) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe present randomized double-blind clinical trial aimed to compare the efficacy in reducing dentin hypersensitivity of a dentifrice formulation containing nano-hydroxyapatite with a fluoride dentifrice and a placebo. METHODS AND MATERIALS: One hundred and five subjects were recruited to participate in the study. A computer-generated random table with blocking to one of the three study treatments was used in order to have 35 subjects per group: (1) nano-hydroxyapatite 2% gel toothpaste fluoride free; (2) fluoride gel toothpaste; (3) placebo. Groups 1, 2, and 3 were instructed to treat their teeth for 10 min twice a day with the provided toothpaste gel. The participant's dentin hypersensitivity was evaluated at baseline and after 2 and 4 weeks using airblast and tactile tests. In addition, a subjective evaluation using a visual analogue scale was used.
resultsSignificant lower values of cold air sensitivity and tactile sensitivity (p < 0.05) were found for the test group at 2 weeks and 4 weeks. In addition, statistically significant (p < 0.05) lower values of sensitivity were reported for group 1 compared to those for groups 2 and 3 at 2 and 4 weeks, respectively. The VAS scores were significantly lower (p < 0.05) in the test group at 2 and 4 weeks compared to those at baseline and in the control groups.
conclusionThe application of nano-hydroxyapatite in gel toothpaste fluoride free is an effective desensitizing agent providing relief from symptoms after 2 and 4 weeks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.