Evidence map›Paper›PMID 28361126›Full record

ArticleJournal of nature and science2017

Pressure sensitivity and phenotypic changes in patients with suspected opioid-induced hyperalgesia being withdrawn from full mu agonists.

Ronald A Wasserman, Afton L Hassett, Steven E Harte, Jenna Goesling, Herbert L Malinoff, Daniel W Berland, Jennifer Zollars, Stephanie E Moser, Chad M Brummett

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of nature and science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03395275 (Intrathecal Morphine Microdose Method Sensory Changes), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03395275 nawithdrawnnot on this mapstarted 2018, after this paper: background citation

Intrathecal Morphine Microdose Method Sensory Changes: A Pilot Study

TypeinterventionalSponsorThe University of Texas Medical Branch, GalvestonRan2018 to 2023Enrolled0ConditionsAnalgesic Drug Dependence, Sensory Disorders, Chronic PainArmsQuantitative Sensory Tests, surveys
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ronald A WassermanDepartment of Anesthesiology, University of Michigan Health System, Ann Arbor, MI, USA.
Afton L HassettDepartment of Anesthesiology, University of Michigan Health System, Ann Arbor, MI, USA.
Steven E HarteDepartment of Anesthesiology, University of Michigan Health System, Ann Arbor, MI, USA.
Jenna GoeslingDepartment of Anesthesiology, University of Michigan Health System, Ann Arbor, MI, USA.
Herbert L MalinoffDepartment of Anesthesiology, University of Michigan Health System, Ann Arbor, MI, USA.
Daniel W BerlandDepartment of Anesthesiology, University of Michigan Health System, Ann Arbor, MI, USA.
Jennifer ZollarsDepartment of Anesthesiology, University of Michigan Health System, Ann Arbor, MI, USA.
Stephanie E MoserDepartment of Anesthesiology, University of Michigan Health System, Ann Arbor, MI, USA.
Chad M BrummettDepartment of Anesthesiology, University of Michigan Health System, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · USMichigan Medicine · US

Funding

Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
NCATS NIH HHS UL1 TR000433
6 · The paper itself

Abstract

objectivesTo assess changes in phenotype and pressure sensitivity in patients with suspected opioid-induced-hyperalgesia (OIH) after transitioning to buprenorphine.

methodsTwenty patients with suspected OIH were enrolled to transition to buprenorphine therapy. Patients completed validated self-report measures at baseline and at 1, 4, 8 weeks, and 6 months after initiation of buprenorphine along with quantitative sensory testing including measures of pressure pain threshold, pain tolerance and Pain 50 (a pain intensity rating).

results20 patients were enrolled, 17 were treated with buprenorphine and 11 completed all assessment points. We found that after transitioning to buprenorphine, patients on higher opioid doses (≥100mg oral morphine equivalents) had significant improvements for some measures including decreased pain severity and fibromyalgia survey scores, fewer neuropathic pain features, less catastrophizing, fewer depressive symptoms, and improved functioning 1-week after transitioning to buprenorphine with an eventual return back to baseline. Although not statistically significant, patients on high dose opioids (≥100mg OME) also showed a trend of decreased pressure sensitivity 1-week after transitioning to buprenorphine with a gradual return back to baseline.

conclusionsOur study is the first to look at pressure pain sensitivity in patients who were taking opioids and transitioned to buprenorphine. These results suggest that the patients most likely to benefit from buprenorphine therapy are those on higher doses. In addition, the eventual return back to baseline on measures of pain phenotype and pressure sensitivity suggests that buprenorphine may over time result in a return of the hyperalgesic effects of a full mu agonist.

Indexed as

BuprenorphineMu Agonists WithdrawalOpioid-Induced HyperalgesiaPhenotypic ChangesPressure Sensitivity

Identifiers

PMID28361126
PMCPMC5370173
OpenAlexW2589919246

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.