Evidence map›Paper›PMID 28361121›Full record

ArticleTransplantation direct2017

A Systematic Review and Meta-Analysis of the Data Behind Current Recommendations for Corticosteroids in Non-HIV-Related PCP: Knowing When You Are on Shaky Foundations.

Patil Injean, Samantha J Eells, Hoover Wu, Imani McElroy, Aric L Gregson, James A McKinnell

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation direct, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

  1. Are CD4Livers · 2026
    Article
  2. Article
  3. JHLT open · 2025
    Article
  4. Review
  5. Observational
  6. Current fungal infection reports · 2024
    Article
  7. Article
  8. Article
  9. Glucocorticoid therapy in respiratory illness: bench to bedside.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2022
    Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Therapy and Management ofJournal of fungi (Basel, Switzerland) · 2018
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Patil InjeanDepartment of Medicine, Western University of Health Sciences, Pomona, CA.
Samantha J EellsDepartment of Epidemiology, UCLA Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, CA.; Science 37, Inc., Los Angeles, CA.
Hoover WuDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Imani McElroyDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Aric L GregsonDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
James A McKinnellScience 37, Inc., Los Angeles, CA.; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.; Division of Infectious Diseases, LA-Biomed Research Institute at Harbor-UCLA Medical Center, Los Angeles, CA.
University of California, Los Angeles · USScience Factory · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
NCATS NIH HHS UL1 TR000124
6 · The paper itself

Abstract

backgroundRandomized trials show a mortality benefit to adjunctive corticosteroids for human immunodeficiency virus (HIV)-related

methodsWe searched MEDLINE from 1966 through 2015. Data on clinical outcomes from NH-PCP were extracted with a standardized instrument. Heterogeneity was assessed with the I

resultsOur search yielded 5044 abstracts, 277 articles were chosen for full review, and 6 articles described outcomes in moderate to severe NH-PCP. Studies were limited by variable definitions, treatment selection bias, concomitant infections and small sample size. Individual studies reported shorter intensive care unit stay and duration of mechanical ventilation of patients given adjunctive corticosteroids. There was no association between corticosteroids and survival in NH-PCP (odds ratio, 0.66; 95% confidence interval, 0.38-1.15;

conclusionsThe literature does not support an association between adjunctive corticosteroids and survival from NH-PCP but data are limited and findings should not be considered conclusive. Further research with improved methodology is needed to better understand the role of adjunctive corticosteroids for NH-PCP.

Identifiers

PMID28361121
PMCPMC5367754
OpenAlexW2588456286

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.