Evidence map›Paper›PMID 28361102›Full record

ArticleMolecular genetics & genomic medicine2017

Gene-centric analysis implicates nuclear encoded mitochondrial protein gene variants in migraine susceptibility.

Shani Stuart, Miles C Benton, David A Eccles, Heidi G Sutherland, Larisa M Haupt, Rodney A Lea, Lyn R Griffiths

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics & genomic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Shani StuartGenomics Research Centre Institute for Biomedical Health and Innovation School of Biomedical Sciences Queensland University of Technology Brisbane Queensland 4059 Australia.
Miles C BentonGenomics Research Centre Institute for Biomedical Health and Innovation School of Biomedical Sciences Queensland University of Technology Brisbane Queensland 4059 Australia.
David A EcclesGenomics Research Centre Institute for Biomedical Health and Innovation School of Biomedical Sciences Queensland University of Technology Brisbane Queensland 4059 Australia.
Heidi G SutherlandGenomics Research Centre Institute for Biomedical Health and Innovation School of Biomedical Sciences Queensland University of Technology Brisbane Queensland 4059 Australia.
Larisa M HauptGenomics Research Centre Institute for Biomedical Health and Innovation School of Biomedical Sciences Queensland University of Technology Brisbane Queensland 4059 Australia.
Rodney A LeaGenomics Research Centre Institute for Biomedical Health and Innovation School of Biomedical Sciences Queensland University of Technology Brisbane Queensland 4059 Australia.
Lyn R GriffithsGenomics Research Centre Institute for Biomedical Health and Innovation School of Biomedical Sciences Queensland University of Technology Brisbane Queensland 4059 Australia.ORCID 0000-0002-6774-5475
Queensland University of Technology · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMigraine is a common neurological disorder which affects a large proportion of the population. The Norfolk Island population is a genetically isolated population and is an ideal discovery cohort for genetic variants involved in complex disease susceptibility given the reduced genetic and environmental heterogeneity. Given that the majority of proteins responsible for mitochondrial function are nuclear encoded, this study aimed to investigate the role of Nuclear Encoded Mitochondrial Protein (NEMP) genes in relation to migraine susceptibility.

methodsA gene-centric association analysis of NEMP genes was undertaken in the most related individuals (

resultsThe discovery phase of the study implicated SNPs in 5 NEMP genes to be associated with migraine susceptibility (

conclusionHere we provide evidence that variation in NEMP genes is associated with migraine susceptibility. This study provides evidence for a link between mitochondrial function and migraine susceptibility.

Indexed as

Complex diseasegene centricmigrainemitochondrial dysfunctionneurogeneticsNorfolk Islandnuclear encoded mitochondrial protein genes

Identifiers

PMID28361102
PMCPMC5370233
OpenAlexW2576429347

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.