ArticleFrontiers in immunology2017
B Cell-Activating Factor Regulates Different Aspects of B Cell Functionality and Is Produced by a Subset of Splenic B Cells in Teleost Fish.
Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Single-cell RNA sequencing reveals IgMZoological research · 2026Article
- Effects ofVaccines · 2026Article
- Single-cell atlas of grass carp (Zoological research · 2025Article
- Immunological memory in a teleost fish: common carp IgMFrontiers in immunology · 2024Article
- Teleost IgDiScience · 2023Article
- An Update on the Evolutionary History of Bregs.Genes · 2022Review
- Functional and Phenotypic Characterization of B Cells in the Teleost Adipose Tissue.Frontiers in immunology · 2022Article
- Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?International journal of molecular sciences · 2021Review
- Article
- A portrait of the immune response to proliferative kidney disease (PKD) in rainbow trout.Parasite immunology · 2020Review
- Recent Advances on Phagocytic B Cells in Teleost Fish.Frontiers in immunology · 2020Review
- Insights Into the Evolution of theFrontiers in immunology · 2020Article
- Teleost IgDCell reports · 2019Article
- CpG Oligodeoxynucleotides Modulate Innate and Adaptive Functions of IgMFrontiers in immunology · 2019Article
- Effects of Cell Differentiation on the Phagocytic Activities of IgMFrontiers in immunology · 2019Article
- Excessive miR-152-3p Results in Increased BAFF Expression in SLE B-Cells by Inhibiting the KLF5 Expression.Frontiers in immunology · 2019Article
- Dysregulation of B Cell Activity During Proliferative Kidney Disease in Rainbow Trout.Frontiers in immunology · 2018Article
- Regulation of IgMFrontiers in immunology · 2018Article
- Novel Insights on the Regulation of B Cell Functionality by Members of the Tumor Necrosis Factor Superfamily in Jawed Fish.Frontiers in immunology · 2018Review
- Herpesvirus Infection Induces both Specific and Heterologous Antiviral Antibodies in Carp.Frontiers in immunology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution.
Funding
Abstract
In mammals, B cell functionality is greatly influenced by cytokines released by innate cells, such as macrophages or dendritic cells, upon the early recognition of common pathogen patterns through invariant receptors. B cell-activating factor (BAFF) is one of these innate B cell-helper signals and plays a key role in the survival and differentiation of B cells. Although, evolutionarily, teleost fish constitute the first animal group in which adaptive immunity based on Ig receptors is present, fish still rely greatly on innate responses. In this context, we hypothesized that BAFF would play a key role in the control of B cell responses in fish. Supporting this, our results show that teleost BAFF recapitulates mammalian BAFF stimulating actions on B cells, upregulating the expression of membrane MHC II, improving the survival of fish naïve B cells and antibody-secreting cells, and increasing the secretion of IgM. Surprisingly, we also demonstrate that BAFF is not only produced in fish by myeloid cells but is also produced by a subset of splenic B cells. Thus, if this B cell-produced BAFF proves to be actively regulating this same B cell subset, our findings point to an ancient mechanism to control B cell differentiation and survival in lower vertebrates, which has been silenced in mammals in physiological conditions, but reemerges under pathological conditions, such as B cell lymphomas and autoimmune diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.