ReviewFrontiers in microbiology2017
The Potential of Systems Biology to Discover Antibacterial Mechanisms of Plant Phenolics.
Review in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 147 citations in OpenAlex.
- Chemical Composition, Biological Activities and Application ofMolecules (Basel, Switzerland) · 2026Review
- Vibrational Spectroscopy Predicts Antimicrobial Activity of Orange Peels: A Case Study on Batch-to-Batch Variation in Food By-Product Valorization.Journal of food science · 2026Article
- ValorizingInternational journal of food science · 2026Article
- Regional variability in phytochemical profiles and bioactivities of macerate and decoction extracts from three medicinal plants of Burkina Faso.Frontiers in plant science · 2026Article
- Phytochemistry, Antimicrobial, Analgesic, Antibiofilm, Diuretic Activities, and Acute Toxicity of Bark Extracts From Three Plants (Khaya senegalensis, Ocimum americanum, and Cassytha filiformis) Collected in Benin.TheScientificWorldJournal · 2026Article
- Antibacterial, Antifungal, Antibiofilm, and Cytotoxicity Activity of Astragalus Baba-Alliar Extract Against Main Causes of Dental Root Canal Infections.Archives of Razi Institute · 2025Article
- Synthesis of Novel Bioactive Lipophilic Hydroxyalkyl Esters and Diesters Based on Hydroxyphenylacetic Acids.Molecules (Basel, Switzerland) · 2025Article
- Evaluation of the antibacterial potential in shoot and root extracts of Eryngium campestre with emphasis on Egyptian ecotype.Scientific reports · 2025Article
- Rapid Bactericidal Activity ofMolecules (Basel, Switzerland) · 2025Article
- Phenolic Compounds fromAntibiotics (Basel, Switzerland) · 2025Review
- Control ofFoods (Basel, Switzerland) · 2025Article
- In Vitro Antibacterial Potential of Herbal Beverage Extracts From Cinnamon, Clove, and Thyme and Their Interactive Antimicrobial Profile With Selected Antibiotics Against Drug-Resistant Clinical Pathogens.Journal of tropical medicine · 2025Article
- Exploring the Correlation Between the Molecular Structure and Biological Activities of Metal-Phenolic Compound Complexes: Research and Description of the Role of Metal Ions in Improving the Antioxidant Activities of Phenolic Compounds.International journal of molecular sciences · 2024Review
- Article
- Vine-Winery Byproducts as Precious Resource of Natural Antimicrobials: In Vitro Antibacterial and Antibiofilm Activity of Grape Pomace Extracts against Foodborne Pathogens.Microorganisms · 2024Article
- Antimicrobial Potential of Polyphenols: An Update on Alternative for Combating Antimicrobial Resistance.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2024Review
- GC-MS profiling of Pistachio vera L., and effect of antioxidant and antimicrobial compounds of it's essential oil compared to chemical counterparts.Scientific reports · 2023Article
- Phenylpropanoid Derivatives and Their Role in Plants' Health and as antimicrobials.Current microbiology · 2023Review
- Antioxidant and Antibacterial Activities of the Leaf and Stem Extracts ofPlants (Basel, Switzerland) · 2023Article
- Growth-stimulating and antioxidant effects of vanillic acid on healthy broiler chickens.Veterinary world · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug resistance of bacterial pathogens is a growing problem that can be addressed through the discovery of compounds with novel mechanisms of antibacterial activity. Natural products, including plant phenolic compounds, are one source of diverse chemical structures that could inhibit bacteria through novel mechanisms. However, evaluating novel antibacterial mechanisms of action can be difficult and is uncommon in assessments of plant phenolic compounds. With systems biology approaches, though, antibacterial mechanisms can be assessed without the bias of target-directed bioassays to enable the discovery of novel mechanism(s) of action against drug resistant microorganisms. This review article summarizes the current knowledge of antibacterial mechanisms of action of plant phenolic compounds and discusses relevant methodology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.