ArticleFrontiers in microbiology2017
Members of the Oral Microbiota Are Associated with IL-8 Release by Gingival Epithelial Cells in Healthy Individuals.
Article in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Green Tea Kombucha Impacts Inflammation and Salivary Microbiota in Individuals with Excess Body Weight: A Randomized Controlled Trial.Nutrients · 2024Trial
- Oral Innate Immunity and the Role of Oral Epithelial Cells.Advances in experimental medicine and biology · 2026Review
- A 7-Week Summer Camp in Antarctica Induces Fluctuations on Human Oral Microbiome, Pro-Inflammatory Markers and Metabolic Hormones Profile.Microorganisms · 2023Article
- Enhanced propagation of Granulicatella adiacens from human oral microbiota by hyaluronan.Scientific reports · 2022Article
- Potential prebiotic substrates modulate composition, metabolism, virulence and inflammatory potential of an in vitro multi-species oral biofilm.Journal of oral microbiology · 2021Article
- Saliva and Serum Cytokine Profiles During Oral Ulceration in Behçet's Disease.Frontiers in immunology · 2021Article
- Investigating the demographic history of Japan using ancient oral microbiota.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- An Ayurvedic herbal extract inhibits oral epithelial cell IL-8 responses to host and bacterial agonists.BMC complementary medicine and therapies · 2020Article
- Alterations of Oral Microbiota in Chinese Patients With Esophageal Cancer.Frontiers in cellular and infection microbiology · 2020Article
- High-Fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett's Esophagus via Interleukin 8 and Alterations to the Gut Microbiome.Gastroenterology · 2019Article
- Oral Mucosal Epithelial Cells.Frontiers in immunology · 2019Review
- Multi-species oral biofilm promotes reconstructed human gingiva epithelial barrier function.Scientific reports · 2018Article
- Association of Coffee and Tea Intake with the Oral Microbiome: Results from a Large Cross-Sectional Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Article
- Dysbiosis of the Urinary Microbiota Associated With Urine Levels of Proinflammatory Chemokine Interleukin-8 in Female Type 2 Diabetic Patients.Frontiers in immunology · 2017Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
The triggers for the onset of oral diseases are still poorly understood. The aim of this study was to characterize the oral bacterial community in healthy humans and its association with nutrition, oral hygiene habits, and the release of the inflammatory marker IL-8 from gingival epithelial cells (GECs) with and without stimulation by bacterial endotoxins to identify possible indicator operational taxonomic units (OTUs) associated with inflammatory marker status. GECs from 21 healthy participants (13 females, 8 males) were incubated with or without addition of bacterial lipopolysaccharides (LPSs), and the oral microbiota was profiled using 16S rRNA gene-targeted sequencing. The basal IL-8 release after 6 h was between 9.9 and 98.2 pg/ml, and bacterial communities were characteristic for healthy oral microbiota. The composition of the oral microbiota was associated with basal IL-8 levels, the intake of meat, tea, white wine, sweets and the use of chewing gum, as well as flossing habits, allergies, gender and body mass index. Additionally, eight OTUs were associated with high basal levels of IL-8 and GEC response to LPS, with high basal levels of IL-8, and 1 with low basal levels of IL8. The identification of indicator bacteria in healthy subjects with high levels of IL-8 release is of importance as they may be promising early warning indicators for the possible onset of oral diseases.
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