ArticleFrontiers in aging neuroscience2017
White Matter Integrity Declined Over 6-Months, but Dance Intervention Improved Integrity of the Fornix of Older Adults.
Article in Frontiers in aging neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 79 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Influence of Fitness on Brain and Cognition II
Exploration of Brain Changes Due to a Targeted Ballet Program in Multiple Sclerosis
The Effect of a Creative Dance-Supported CO-OP Approach on Executive Functions, Attention, Memory, and Dual-Task Performance in Older Adults With Mild Cognitive Impairment: A Randomized Controlled Trial
Who cites it
79 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Effect of dance intervention on cardiorespiratory fitness and quality of life of older adults: a systematic review and meta-analysis.Frontiers in sports and active living · 2026Pooled it
- Effects of exercise interventions on cognitive function in patients with cognitive dysfunction: an umbrella review of meta-analyses.Frontiers in aging neuroscience · 2025Pooled it
- Effects of different long-term exercise interventions on working memory in children and adolescents: a network meta-analysis.Frontiers in psychology · 2025Pooled it
- The Effectiveness of Dance Interventions on Psychological and Cognitive Health Outcomes Compared with Other Forms of Physical Activity: A Systematic Review with Meta-analysis.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- Neuroscience meets behavior: A systematic literature review on magnetic resonance imaging of the brain combined with real-world digital phenotyping.Human brain mapping · 2024Pooled it
- Associations of cardiorespiratory fitness and exercise with brain white matter in healthy adults: A systematic review and meta-analysis.Brain imaging and behavior · 2022Pooled it
- Exercise interventions preserve hippocampal volume: A meta-analysis.Hippocampus · 2021Pooled it
- Effects of Dance Interventions on Cognition, Psycho-Behavioral Symptoms, Motor Functions, and Quality of Life in Older Adult Patients With Mild Cognitive Impairment: A Meta-Analysis and Systematic Review.Frontiers in aging neuroscience · 2021Pooled it
- Effects of Dance Movement Therapy and Dance on Health-Related Psychological Outcomes. A Meta-Analysis Update.Frontiers in psychology · 2019Pooled it
- Neurologic dance training and home exercise improve motor-cognitive dual-task function similarly, but through potentially different mechanisms, among breast cancer survivors with chemotherapy-induced neuropathy: Initial results of a randomized, controlled clinical trial.Journal of Alzheimer's disease : JAD · 2025Trial
- Effect of physical exercise on white matter microstructure in chemotherapy-treated breast cancer patients: a randomized controlled trial (PAM study).Brain imaging and behavior · 2025Trial
- Hippocampal maintenance after a 12-month physical activity intervention in older adults: The REACT MRI study.NeuroImage. Clinical · 2022Trial
- Sensor-measured sedentariness and physical activity are differentially related to fluid and crystallized abilities in aging.Psychology and aging · 2020Trial
- Nutritional supplementation boosts aerobic exercise effects on functional brain systems.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Trial
- International Ballroom Dancing Against Neurodegeneration: A Randomized Controlled Trial in Greek Community-Dwelling Elders With Mild Cognitive impairment.American journal of Alzheimer's disease and other dementias · 2017Trial
- Effects of a randomized exercise trial on physical activity, psychological distress and quality of life in older adults.General hospital psychiatry · 2017Trial
- Design, development, and validation of a multimodal synergy-based intuitive virtual and augmented reality therapy platform for mental health.Frontiers in robotics and AI · 2026Article
- Effects of Aging, Estimated Fitness, and Cerebrovascular Status on White Matter Microstructural Health.Human brain mapping · 2025Article
- Assessing Exercise and Fitness-Related Brain Health Using Multi-modal Magnetic Resonance Imaging Outcomes.Advances in neurobiology · 2025Review
- 16 weeks of moderate intensity resistance exercise improves strength but is insufficient to alter brain structure in Gulf War Veterans with chronic musculoskeletal pain: a randomized controlled trial.Frontiers in neuroscience · 2025Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Degeneration of cerebral white matter (WM), or structural disconnection, is one of the major neural mechanisms driving age-related decline in cognitive functions, such as processing speed. Past cross-sectional studies have demonstrated beneficial effects of greater cardiorespiratory fitness, physical activity, cognitive training, social engagement, and nutrition on cognitive functioning and brain health in aging. Here, we collected diffusion magnetic resonance (MRI) imaging data from 174 older (age 60-79) adults to study the effects of 6-months lifestyle interventions on WM integrity. Healthy but low-active participants were randomized into Dance, Walking, Walking + Nutrition, and Active Control (stretching and toning) intervention groups (NCT01472744 on ClinicalTrials.gov). Only in the fornix there was a time × intervention group interaction of change in WM integrity: integrity declined over 6 months in all groups but increased in the Dance group. Integrity in the fornix at baseline was associated with better processing speed, however, change in fornix integrity did not correlate with change in processing speed. Next, we observed a decline in WM integrity across the majority of brain regions in all participants, regardless of the intervention group. This suggests that the aging of the brain is detectable on the scale of 6-months, which highlights the urgency of finding effective interventions to slow down this process. Magnitude of WM decline increased with age and decline in prefrontal WM was of lesser magnitude in older adults spending less time sedentary and more engaging in moderate-to-vigorous physical activity. In addition, our findings support the anterior-to-posterior gradient of greater-to-lesser decline, but only in the in the corpus callosum. Together, our findings suggest that combining physical, cognitive, and social engagement (dance) may help maintain or improve WM health and more physically active lifestyle is associated with slower WM decline. This study emphasizes the importance of a physically active and socially engaging lifestyle among aging adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.