Evidence map›Paper›PMID 28360842›Full record

ReviewFrontiers in cellular neuroscience2017

Neuroplastic Changes Following Brain Ischemia and their Contribution to Stroke Recovery: Novel Approaches in Neurorehabilitation.

Claudia Alia, Cristina Spalletti, Stefano Lai, Alessandro Panarese, Giuseppe Lamola, Federica Bertolucci, Fabio Vallone, Angelo Di Garbo, Carmelo Chisari, Silvestro Micera and 1 more

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cellular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04824482 (GAIT Recovery in Patients aFter Acute Ischemic STroke), which is not on this map. Cited by 121 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 9 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04824482 narecruitingnot on this mapstarted 2020, after this paper: background citation

GAIT Recovery in Patients aFter Acute Ischemic STroke: A Randomized Comparison of Robot-assisted and Therapist-assisted Gait Training on a Treadmill.

TypeinterventionalSponsorUniversity Hospital OlomoucRan2020 to 2026Enrolled120ConditionsIschemic StrokeArmsRobot-assisted treadmill gait training (RTGT), Therapist-assisted treadmill gait training (TTGT)
3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 9 syntheses or guidelines pooled it, 236 citations in OpenAlex.

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61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Claudia AliaCNR Neuroscience Institute, National Research Council (CNR)Pisa, Italy; Laboratory of Biology, Scuola Normale SuperiorePisa, Italy.
Cristina SpallettiCNR Neuroscience Institute, National Research Council (CNR) Pisa, Italy.
Stefano LaiTranslational Neural Engineering Area, The BioRobotics Institute, Scuola Superiore Sant'Anna Pontedera, Italy.
Alessandro PanareseTranslational Neural Engineering Area, The BioRobotics Institute, Scuola Superiore Sant'Anna Pontedera, Italy.
Giuseppe LamolaDepartment of Neuroscience, Unit of Neurorehabilitation-University Hospital of Pisa Pisa, Italy.
Federica BertolucciDepartment of Neuroscience, Unit of Neurorehabilitation-University Hospital of Pisa Pisa, Italy.
Fabio ValloneTranslational Neural Engineering Area, The BioRobotics Institute, Scuola Superiore Sant'AnnaPontedera, Italy; CNR Biophysics Institute, National Research Council (CNR)Pisa, Italy; Neural Computation Laboratory, Center for Neuroscience and Cognitive Systems @UniTn, Italian institute of Technology (IIT)Rovereto, Italy.
Angelo Di GarboCNR Biophysics Institute, National Research Council (CNR) Pisa, Italy.
Carmelo ChisariDepartment of Neuroscience, Unit of Neurorehabilitation-University Hospital of Pisa Pisa, Italy.
Silvestro MiceraTranslational Neural Engineering Area, The BioRobotics Institute, Scuola Superiore Sant'AnnaPontedera, Italy; Ecole Polytechnique Federale de Lausanne (EPFL), Bertarelli Foundation Chair in Translational NeuroEngineering Laboratory, Center for Neuroprosthetics and Institute of BioengineeringLausanne, Switzerland.
Matteo CaleoCNR Neuroscience Institute, National Research Council (CNR) Pisa, Italy.
Azienda Ospedaliera Universitaria Pisana · ITNeuroscience Institute · ITScuola Superiore Sant'Anna · ITInstituto Biofisika · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic damage to the brain triggers substantial reorganization of spared areas and pathways, which is associated with limited, spontaneous restoration of function. A better understanding of this plastic remodeling is crucial to develop more effective strategies for stroke rehabilitation. In this review article, we discuss advances in the comprehension of post-stroke network reorganization in patients and animal models. We first focus on rodent studies that have shed light on the mechanisms underlying neuronal remodeling in the perilesional area and contralesional hemisphere after motor cortex infarcts. Analysis of electrophysiological data has demonstrated brain-wide alterations in functional connectivity in both hemispheres, well beyond the infarcted area. We then illustrate the potential use of non-invasive brain stimulation (NIBS) techniques to boost recovery. We finally discuss rehabilitative protocols based on robotic devices as a tool to promote endogenous plasticity and functional restoration.

Indexed as

callosal connectionslocal field potentialsmotor cortexnon-invasive brain stimulationplasticityrehabilitationroboticsstroke

Identifiers

PMID28360842
PMCPMC5352696
OpenAlexW2603314637

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.