ArticleThrombosis journal2017
Impact of blood hypercoagulability on in vitro fertilization outcomes: a prospective longitudinal observational study.
Article in Thrombosis journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Association of infertility treatments and incidence of stroke among women: a systematic review.Reproduction & fertility · 2025Pooled it
- Prothrombotic fibrin clot phenotype in pregnant women after ovarian stimulation: associations with neuropeptides.Hormones (Athens, Greece) · 2026Article
- Unfavorably altered fibrin clot properties in women with unexplained infertility: association with pregnancy outcomes.Archives of gynecology and obstetrics · 2026Article
- Article
- Glycemic index, glycemic load, dietary inflammatory index, and risk of infertility in women.Food science & nutrition · 2023Article
- Personalized Nutrition in the Management of Female Infertility: New Insights on Chronic Low-Grade Inflammation.Nutrients · 2022Review
- Involvement of single nucleotide polymorphisms in ovarian poor response.Journal of assisted reproduction and genetics · 2021Article
- An enhanced clot growth rate before in vitro fertilization decreases the probability of pregnancy.PloS one · 2019Observational
- A Systematic Evidence-Based Review Regarding miRNA Polymorphisms in Recurrent Implantation Failure.Reproductive medicine and biologyReview
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBlood coagulation plays a crucial role in the blastocyst implantation process and its alteration may be related to in vitro fertilization (IVF) failure. We conducted a prospective observational longitudinal study in women eligible for IVF to explore the association between alterations of coagulation with the IVF outcome and to identify the biomarkers of hypercoagulability which are related with this outcome.
methodsThirty-eight women eligible for IVF (IVF-group) and 30 healthy, age-matched women (control group) were included. In the IVF-group, blood was collected at baseline, 5-8 days after administration of gonadotropin-releasing hormone agonist (GnRH), before and two weeks after administration of human follicular stimulating hormone (FSH). Pregnancy was monitored by measurement of
resultsPositive IVF occurred in 15 women (40%). At baseline, the IVF-group showed significantly increased TG, TFa and TMa and significantly shorter Procoag-PPL versus the control group. After initiation of hormone treatment TG was significantly higher in the IVF-positive as compared to the IVF-negative group. At all studied points, the Procoag-PPL was significantly shorter and the levels of TFa were significantly higher in the IVF-negative group compared to the IVF-positive one. The D-Dimers were higher in the IVF negative as compared to IVF positive group. Multivariate analysis retained the Procoag-PPL and TG as predictors for the IVF outcome.
conclusionsDiagnosis of women with hypercoagulability and their stratification to risk of IVF failure using a model based on the Procoag-PPL and TG is a feasible strategy for the optimization of IVF efficiency that needs to be validated in prospective trials.
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