ArticleIranian journal of medical sciences2017
Comparing Adrenaline with Tranexamic Acid to Control Acute Endobronchial Bleeding: A Randomized Controlled Trial.
Article in Iranian journal of medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Effects of Tranexamic Acid on Hemoptysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Clinical drug investigation · 2020Pooled it
- Review
- Tranexamic acid in the management of post-procedural bleeding in bronchoscopy: A comprehensive review.Lung India : official organ of Indian Chest Society · 2026Article
- Management of severe acute pulmonary haemorrhage in children.The Lancet. Child & adolescent health · 2025Review
- Advances in the study of nebulized tranexamic acid for pulmonary hemorrhage.European journal of clinical pharmacology · 2025Review
- ABCDE Approach for Massive Hemoptysis: A Novel Cognitive Aid.ATS scholar · 2022Article
- Management of life-threatening hemoptysis in the ICU.Journal of thoracic disease · 2021Review
- Equipment and procedural setup for interventional pulmonology procedures in the intensive care unit.Journal of thoracic disease · 2021Review
- Clinical Approach to and Work-up of Bleeding Patients.Seminars in interventional radiology · 2020Review
- Bronchoscopic delivery of aminocaproic acid as a treatment for pulmonary bleeding: A case series.Pulmonary pharmacology & therapeutics · 2020Article
- Inhaled Tranexamic Acid As a Novel Treatment for Pulmonary Hemorrhage in Critically Ill Pediatric Patients: An Observational Study.Critical care explorations · 2020Article
- Effect of tranexamic acid on mortality in patients with haemoptysis: a nationwide study.Critical care (London, England) · 2019Article
- Airway trauma during difficult intubation… from the frying pan into the fire?Indian journal of anaesthesia · 2017Article
- Approach to Hemoptysis in the Modern Era.Canadian respiratory journal · 2017Review
- The efficacy and application of tranexamic acid in emergency medicine: Emergency Medicine Association of Türkiye clinical policy- 2024.Turkish journal of emergency medicineArticle
- The application of tranexamic acid in respiratory intervention complicated with bleeding.Therapeutic advances in respiratory diseaseReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHemoptysis occurs due to either pulmonary diseases or bronchoscopy interventions. The aim of the present study was to compare the efficacy of the endobronchial instillation of adrenaline with that of tranexamic acid.
methodsFifty patients were randomly selected as 2 double-blinded sample groups (n=25). In these patients, bleeding could not be controlled with cold saline lavage during bronchoscopy and they, therefore, required prescription of another medicine. Adrenaline (1 mg) in one group and tranexamic acid (500 mg) in the other group were diluted in 20 mL of normal saline and instilled through the bronchoscope. This technique was repeated 3 times at 90-second intervals, if necessary. In the case of persistent bleeding, 90 seconds after the last dose, a second medicine was given for bleeding control. Observation of clot through the bronchoscope meant that the bleeding had stopped. The efficacy of tranexamic acid and adrenaline was evaluated and then compared using the Mann-Whitney test.
resultsThe time of bleeding control had no significant difference between tranexamic acid and adrenaline (P=0.908). Another analysis was done to evaluate bleeding control with a second medicine; the results showed that 1 (4%) patient in the tranexamic acid and 8 (32%) in the adrenaline group needed the second medicine and there was no significant difference between the 2 groups (P=0.609).
conclusionOur results suggested that tranexamic acid by endobronchial instillation was as efficient as adrenaline in controlling hemoptysis and required less frequent use of a second medicine.
Indexed as
Identifiers
28360438PMC5366360W2589724329What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.