ArticleInternational journal of obesity (2005)2017
Sex differences in the influence of body mass index on anatomical architecture of brain networks.
Article in International journal of obesity (2005), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Neuroimaging Investigations of Obesity: a Review of the Treatment of Sex from 2010.Current obesity reports · 2023Pooled it
- Alterations in reward network functional connectivity are associated with increased food addiction in obese individuals.Scientific reports · 2021Trial
- Sex-related difference of subcortical gray matter volume associated with crystallized intelligence in young adults with obesity.Biology of sex differences · 2026Article
- Early life adversity impacts alterations in brain structure and food addiction in individuals with high BMI.Scientific reports · 2024Article
- Influence of insulin sensitivity on food cue evoked functional brain connectivity in children.bioRxiv : the preprint server for biology · 2024Article
- The genetics of a "femaleness/maleness" score in cardiometabolic traits in the UK biobank.Scientific reports · 2023Article
- Machine learning model to predict obesity using gut metabolite and brain microstructure data.Scientific reports · 2023Article
- Brain functional and structural magnetic resonance imaging of obesity and weight loss interventions.Molecular psychiatry · 2023Review
- Overweight/Obesity-related microstructural alterations of the fimbria-fornix in the ABCD study: The role of aerobic physical activity.PloS one · 2023Article
- Considering Sex as a Biological Variable in Basic and Clinical Studies: An Endocrine Society Scientific Statement.Endocrine reviews · 2021Article
- Whole-brain functional connectivity correlates of obesity phenotypes.Human brain mapping · 2020Article
- Sexes on the brain: Sex as multiple biological variables in the neuronal control of feeding.Biochimica et biophysica acta. Molecular basis of disease · 2020Review
- Article
- Neuroimaging of Sex/Gender Differences in Obesity: A Review of Structure, Function, and Neurotransmission.Nutrients · 2020Review
- History of early life adversity is associated with increased food addiction and sex-specific alterations in reward network connectivity in obesity.Obesity science & practice · 2019Article
- Prediction of future weight change with dopamine transporter in patients with Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2019Article
- Sex Commonalities and Differences in Obesity-Related Alterations in Intrinsic Brain Activity and Connectivity.Obesity (Silver Spring, Md.) · 2018Article
- Article
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
BACKGROUND/
objectivesThe brain has a central role in regulating ingestive behavior in obesity. Analogous to addiction behaviors, an imbalance in the processing of rewarding and salient stimuli results in maladaptive eating behaviors that override homeostatic needs. We performed network analysis based on graph theory to examine the association between body mass index (BMI) and network measures of integrity, information flow and global communication (centrality) in reward, salience and sensorimotor regions and to identify sex-related differences in these parameters. SUBJECTS/
methodsStructural and diffusion tensor imaging were obtained in a sample of 124 individuals (61 males and 63 females). Graph theory was applied to calculate anatomical network properties (centrality) for regions of the reward, salience and sensorimotor networks. General linear models with linear contrasts were performed to test for BMI and sex-related differences in measures of centrality, while controlling for age.
resultsIn both males and females, individuals with high BMI (obese and overweight) had greater anatomical centrality (greater connectivity) of reward (putamen) and salience (anterior insula) network regions. Sex differences were observed both in individuals with normal and elevated BMI. In individuals with high BMI, females compared to males showed greater centrality in reward (amygdala, hippocampus and nucleus accumbens) and salience (anterior mid-cingulate cortex) regions, while males compared to females had greater centrality in reward (putamen) and sensorimotor (posterior insula) regions.
conclusionsIn individuals with increased BMI, reward, salience and sensorimotor network regions are susceptible to topological restructuring in a sex-related manner. These findings highlight the influence of these regions on integrative processing of food-related stimuli and increased ingestive behavior in obesity, or in the influence of hedonic ingestion on brain topological restructuring. The observed sex differences emphasize the importance of considering sex differences in obesity pathophysiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.