Evidence map›Paper›PMID 28360407›Full record

SynthesisMedical science monitor basic research2017

Predictive Role of Coagulation, Fibrinolytic, and Endothelial Markers in Patients with Atrial Fibrillation, Stroke, and Thromboembolism: A Meta-Analysis, Meta-Regression, and Systematic Review.

Alexander Weymann, Anton Sabashnikov, Sadeq Ali-Hasan-Al-Saegh, Aron-Frederik Popov, Seyed Jalil Mirhosseini, William L Baker, Mohammadreza Lotfaliani, Tong Liu, Hamidreza Dehghan, Senol Yavuz and 10 more

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Medical science monitor basic research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 45 citations in OpenAlex.

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  11. The Role of Major Inflammatory Biomarkers in the Pathogenesis of Atrial Fibrillation.The Journal of innovations in cardiac rhythm management · 2022
    Article
  12. Article
  13. Changes of new coagulation markers in healthy pregnant women and establishment of reference intervals in Changsha.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 13 institutions in 9 countries.

Alexander WeymannDepartment of Cardiac Surgery, University Hospital Oldenburg, European Medical School Oldenburg-Groningen, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
Anton SabashnikovDepartment of Cardiothoracic Transplantation and Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, Harefield Hospital, Harefield Middlesex, United Kingdom.
Sadeq Ali-Hasan-Al-SaeghCardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Aron-Frederik PopovDepartment of Cardiac Surgery, University Hospital Frankfurt am Main, Frankfurt am Main, Germany.
Seyed Jalil MirhosseiniCardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
William L Baker, University of Connecticut/Hartford Hospital Evidence-Based Practice Center, Hartford, CT, USA.
Mohammadreza LotfalianiCardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Tong LiuTianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, 2nd Hospital of Tianjin Medical University, Tianjin, China (mainland).
Hamidreza DehghanDepartment of Health Technology Assessment, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
Senol YavuzDepartment of Cardiovascular Surgery, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey.
Michel Pompeu Barros de Oliveira SáDivision of Cardiovascular Surgery, Pronto Socorro Cardiológico de Pernambuco - PROCAPE, Recife, Brazil.
Jae-Sik JangDepartment of Cardiology, Busan Paik Hospital, Inje University College of Medicine, Busan, South Korea.
Mohamed ZeriouhDepartment of Cardiothoracic Transplantation and Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, Harefield Hospital, Harefield Middlesex, United Kingdom.
Lei MengTianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, 2nd Hospital of Tianjin Medical University, Tianjing, China (mainland).
Fabrizio D'AscenzoDivision of Cardiology, Department of Medical Sciences, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.
Abhishek J DeshmukhMayo Clinic Heart Rhythm Section, Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
Guiseppe Biondi-ZoccaiDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy.
Pascal M DohmenDepartment of Cardiac Surgery, University Hospital Oldenburg, European Medical School Oldenburg-Groningen, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
Hugh CalkinsDepartment of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Integrated Meta-Analysis Of Cardiac Cardiac Surgery And Cardiology-Group Imcsc-Group0, 0.
Shahid Sadoughi University of Medical Sciences and Health Services · IRCarl von Ossietzky Universität Oldenburg · DEBursa Yuksek Ihtisas Egitim Ve Arastirma Hastanesi · TRHarefield Hospital · GBInje University Busan Paik Hospital · KRIstituto Neurologico Mediterraneo · ITJohns Hopkins University · USRoyal Brompton & Harefield NHS Foundation Trust · GBSecond Hospital of Tianjin Medical University · CNTianjin Medical University · CNUniversidade de Pernambuco · BRUniversity of Connecticut · USUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND The pathophysiological mechanism associated with the higher prothrombotic tendency in atrial fibrillation (AF) is complex and multifactorial. However, the role of prothrombotic markers in AF remains inconclusive. MATERIAL AND METHODS We conducted a meta-analysis of observational studies evaluating the association of coagulation activation, fibrinolytic, and endothelial function with occurrence of AF and clinical adverse events. A comprehensive subgroup analysis and meta-regression was performed to explore potential sources of heterogeneity. RESULTS A literature search of major databases retrieved 1703 studies. After screening, a total of 71 studies were identified. Pooled analysis showed the association of coagulation markers (D-dimer (weighted mean difference (WMD) =197.67 and p<0.001), fibrinogen (WMD=0.43 and p<0.001), prothrombin fragment 1-2 (WMD=0.53 and p<0.001), antithrombin III (WMD=23.90 and p=0.004), thrombin-antithrombin (WMD=5.47 and p=0.004));  fibrinolytic markers (tissue-type plasminogen activator (t-PA) (WMD=2.13 and p<0.001), plasminogen activator inhibitor (WMD=11.44 and p<0.001), fibrinopeptide-A (WMD=4.13 and p=0.01)); and  endothelial markers (von Willebrand factor (WMD=27.01 and p<0.001) and soluble thrombomodulin (WMD=3.92 and p<0.001)) with AF. CONCLUSIONS The levels of coagulation, fibrinolytic, and endothelial markers have been reported to be significantly higher in AF patients than in SR patients.

Indexed as

Atrial FibrillationBiomarkersBlood Coagulation FactorsFibrin Fibrinogen Degradation ProductsFibrinolytic AgentsHumansStrokeThromboembolismTissue Plasminogen ActivatorBiomarkersBlood Coagulation FactorsFibrin Fibrinogen Degradation Productsfibrin fragment DFibrinolytic AgentsPLAT protein, humanTissue Plasminogen ActivatorAtrial FibrillationBlood Coagulation DisordersFibrinolysis

Identifiers

PMID28360407
PMCPMC5452871
OpenAlexW2606602370

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.