Evidence map›Paper›PMID 28360329›Full record

ArticleScience (New York, N.Y.)2017

Aging increases cell-to-cell transcriptional variability upon immune stimulation.

Celia Pilar Martinez-Jimenez, Nils Eling, Hung-Chang Chen, Catalina A Vallejos, Aleksandra A Kolodziejczyk, Frances Connor, Lovorka Stojic, Timothy F Rayner, Michael J T Stubbington, Sarah A Teichmann and 3 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 200 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
200citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

200 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  14. Chromatin accessibility regulates age-dependent nuclear mechanotransduction.Proceedings of the National Academy of Sciences of the United States of America · 2026
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140 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Celia Pilar Martinez-Jimenez *University of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, CB2 0RE, UK.
Nils Eling *University of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, CB2 0RE, UK.
Hung-Chang ChenUniversity of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, CB2 0RE, UK.
Catalina A VallejosEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Aleksandra A KolodziejczykWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Frances ConnorUniversity of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, CB2 0RE, UK.
Lovorka StojicUniversity of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, CB2 0RE, UK.
Timothy F RaynerUniversity of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, CB2 0RE, UK.
Michael J T StubbingtonEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Sarah A TeichmannWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Maike de la RocheUniversity of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, CB2 0RE, UK.
John C MarioniUniversity of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, CB2 0RE, UK.
Duncan T OdomUniversity of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, CB2 0RE, UK.

Funding

Biotechnology and Biological Sciences Research Council BB/I015914/3Cancer Research UK 17043Cancer Research UK 20412Cancer Research UK 22231Cancer Research UK 22257Cancer Research UK A15603Cancer Research UK A22257European Research Council 260507European Research Council 615584European Research Council 646794Medical Research Council MC_UP_0801/1Medical Research Council MC_UU_00002/10Wellcome Trust 098051Wellcome Trust 107609Wellcome Trust 202878ODOMWellcome Trust 202878/Z/16/Z
6 · The paper itself

Abstract

Aging is characterized by progressive loss of physiological and cellular functions, but the molecular basis of this decline remains unclear. We explored how aging affects transcriptional dynamics using single-cell RNA sequencing of unstimulated and stimulated naïve and effector memory CD4

Indexed as

TranscriptomeAgingAnimalsCD4-Positive T-LymphocytesCellular SenescenceGenetic VariationImmunologic MemoryLymphocyte ActivationMaleMiceMice, Inbred C57BLReceptors, Antigen, T-CellSequence Analysis, RNASingle-Cell AnalysisReceptors, Antigen, T-Cell

Identifiers

PMID28360329
PMCPMC5405862

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.