Evidence map›Paper›PMID 28360260›Full record

ReviewCirculation. Cardiovascular imaging2017

Multiparametric Imaging of Organ System Interfaces.

Katrien Vandoorne, Matthias Nahrendorf

Abstract readReview
In one paragraph

Review in Circulation. Cardiovascular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Myeloid cells in cardiovascular organs.Journal of internal medicine · 2019
    Review
  5. Macrophages and Cardiovascular Health.Physiological reviews · 2018
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Katrien VandoorneFrom the Center for Systems Biology (K.V., M.N.) and Department of Imaging (K.V., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston; and Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston (M.N.).
Matthias NahrendorfFrom the Center for Systems Biology (K.V., M.N.) and Department of Imaging (K.V., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston; and Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston (M.N.). mnahrendorf@mgh.harvard.edu.

Funding

Lifestyle effects on hematopoiesis and atherosclerosisR01HL128264 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAHRENDORF, MATTHIAS, SWIRSKI, FILIP K · 2015 to 2018
$3.3M
Dynamic interactions between ischemic stroke, immunity and the bone marrowR01NS084863 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MOSKOWITZ, MICHAEL A., NAHRENDORF, MATTHIAS · 2014 to 2018
$3.2M
PET/MRI of cardiac repairR01HL096576 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAHRENDORF, MATTHIAS · 2009 to 2017
$2.8M
Quantitative nanoparticle imaging of macrophagesR01HL131495 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAHRENDORF, MATTHIAS, WEISSLEDER, MD, PHD, RALPH · 2017 to 2020
$2.7M
Interfering with the macrophage life cycle of atherosclerosisR01HL125428 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ANDERSON, DANIEL G, NAHRENDORF, MATTHIAS · 2017 to 2020
$1.9M
Cell-Cell Interaction in Heart FailureR01HL117829 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAHRENDORF, MATTHIAS · 2014 to 2017
$1.7M
Pathogen specific imaging of endocarditisR01HL114477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAHRENDORF, MATTHIAS, PANIZZI, PETER ROLF · 2013 to 2016
$1.7M
NHLBI NIH HHS R01 HL096576NHLBI NIH HHS R01 HL114477NHLBI NIH HHS R01 HL117829NHLBI NIH HHS R01 HL125428NHLBI NIH HHS R01 HL128264NHLBI NIH HHS R01 HL131495NINDS NIH HHS R01 NS084863
6 · The paper itself

Abstract

Cardiovascular diseases are a consequence of genetic and environmental risk factors that together generate arterial wall and cardiac pathologies. Blood vessels connect multiple systems throughout the entire body and allow organs to interact via circulating messengers. These same interactions facilitate nervous and metabolic system's influence on cardiovascular health. Multiparametric imaging offers the opportunity to study these interfacing systems' distinct processes, to quantify their interactions, and to explore how these contribute to cardiovascular disease. Noninvasive multiparametric imaging techniques are emerging tools that can further our understanding of this complex and dynamic interplay. Positron emission tomography/magnetic resonance imaging and multichannel optical imaging are particularly promising because they can simultaneously sample multiple biomarkers. Preclinical multiparametric diagnostics could help discover clinically relevant biomarker combinations pivotal for understanding cardiovascular disease. Interfacing systems important to cardiovascular disease include the immune, nervous, and hematopoietic systems. These systems connect with classical cardiovascular organs, such as the heart and vasculature, and with the brain. The dynamic interplay between these systems and organs enables processes, such as hemostasis, inflammation, angiogenesis, matrix remodeling, metabolism, and fibrosis. As the opportunities provided by imaging expand, mapping interconnected systems will help us decipher the complexity of cardiovascular disease and monitor novel therapeutic strategies.

Indexed as

Systems IntegrationAnimalsBiomarkersCardiovascular DiseasesCardiovascular SystemGenetic MarkersGenetic Predisposition to DiseaseHematopoietic SystemHumansInflammation MediatorsMultimodal ImagingNeuroimmunomodulationPhenotypePredictive Value of TestsPrognosisSystems BiologyBiomarkersGenetic MarkersInflammation Mediatorsbiomarkersbraincardiovascular diseaseshematopoietic systemsystems biology

Identifiers

PMID28360260
PMCPMC5419074

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.