ArticleBMJ open2017
Three-year outcomes after acute kidney injury: results of a prospective parallel group cohort study.
Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05247502 (Impact of the Characteristics of Acute Renal Failure in Intensive Care on the Long-term Renal Prognosis), which is not on this map. Cited by 61 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of the Characteristics of Acute Renal Failure in Intensive Care on the Long-term Renal Prognosis: Prospective Multicenter Cohort Study
Who cites it
61 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Long-term risks of adverse kidney outcomes after acute kidney injury: a systematic review and meta-analysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Pooled it
- Health inequalities and outcomes following acute kidney injury: a systematic review & meta-analyses of observational studies.BMC nephrology · 2025Pooled it
- Ethnicity-Stratified Analysis of the Association between TNF-BioMed research international · 2020Pooled it
- Acute kidney disease after acute kidney injury: incidence, risk factors, and association withRenal failure · 2026Article
- Early ultrasound markers for predicting the transition from acute kidney injury to chronic kidney disease and treatment response in a murine model.Ultrasonography (Seoul, Korea) · 2026Article
- Quantifying Change in Proteinuria After Acute Kidney Injury Among Patients With Chronic Kidney Disease: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.Kidney medicine · 2026Article
- Optimizing Proteinuria Evaluation and Management after Acute Kidney Injury: Insights from the Chronic Renal Insufficiency Cohort Study.Kidney360 · 2026Article
- Preliminary study investigating the role of estimated glomerular filtration rate, proteinuria and hypertension to inform on chronic kidney disease after acute kidney injury.The Journal of small animal practice · 2026Article
- Cardiac surgery-associated acute kidney injury in a single healthcare system: a retrospective observational study.Critical care science · 2026Observational
- Crosstalk between macrophages and adjacent cells in AKI to CKD transition.Renal failure · 2025Review
- Progression of acute kidney injury to chronic kidney disease: a prospective cohort study.Pediatric nephrology (Berlin, Germany) · 2025Article
- Pediatric acute kidney injury is associated with impairment in nicotinamide adenine dinucleotide (NAD+) metabolism.Pediatric nephrology (Berlin, Germany) · 2025Observational
- State of the art: Renal recovery after AKI - from basic science to clinical practice.Intensive care medicine · 2025Review
- Collagen type III formation but not degradation is associated with risk of kidney disease progression and mortality after acute kidney injury.Clinical kidney journal · 2025Article
- Incidence and Predictors of Acute Kidney Injury Among Critically Ill Adult Patients Admitted at Mbarara Regional Referral Hospital.International journal of nephrology and renovascular disease · 2025Article
- Transformation of acute kidney injury to chronic kidney disease: the interaction between mitophagy and NLRP3 inflammasome.Frontiers in molecular biosciences · 2025Review
- ATP dynamics as a predictor of future podocyte structure and function after acute ischemic kidney injury in female mice.Nature communications · 2024Article
- Iron metabolism indexes as predictors of the incidence of cardiac surgery-associated acute kidney surgery.Journal of cardiothoracic surgery · 2024Observational
- Optimization of kidney function in cardiac surgery patients with intra-abdominal hypertension: expert opinion.Perioperative medicine (London, England) · 2024Review
- Effect of rehabilitation on renal outcomes after acute kidney injury associated with cardiovascular disease: a retrospective analysis.BMC nephrology · 2024Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesUsing a prospective study design, we aimed to characterise the effect of acute kidney injury (AKI) on long-term changes in renal function in a general hospital population.
participantsHospitalised patients with AKI (exposed) and hospitalised patients without AKI (non-exposed), recruited at 3 months after hospital admission.
designProspective, matched parallel group cohort study, in which renal function and proteinuria were measured at 3 months, 1 year and 3 years.
settingSingle UK centre. CLINICAL END POINTS: Clinical end points at 3 years were comparison of the following variables between exposed and non-exposed groups: renal function, prevalence of proteinuria and albuminuria and chronic kidney disease (CKD) progression/development at each time point. CKD progression was defined as a decrease in the estimated glomerular filtration rate (eGFR) of ≥25% associated with a decline in eGFR stage.
results300 exposed and non-exposed patients were successfully matched 1:1 for age and baseline renal function; 70% of the exposed group had AKI stage 1. During follow-up, the AKI group had lower eGFR than non-exposed patients at each time point. At 3 years, the mean eGFR was 60.7±21 mL/min/1.73 m
conclusionsAKI is associated with deterioration in renal function to 3 years, even in an unselected population with predominantly AKI stage 1. Non-recovery from AKI is an important factor determining long-term outcome.
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