Evidence map›Paper›PMID 28360247›Full record

Trial reportBMJ open2017

Economic evaluation of aerobic exercise training in older adults with vascular cognitive impairment: PROMoTE trial.

Jennifer C Davis, Ging-Yuek Robin Hsiung, Stirling Bryan, John R Best, Janice J Eng, Michelle Munkacsy, Winnie Cheung, Bryan Chiu, Claudia Jacova, Philip Lee and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01027858 (Role of Exercise on Cognition and Function in Seniors With Vascular Cognitive Impairment), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01027858 nacompletednot on this map

Role of Exercise on Cognition and Function in Seniors With Vascular Cognitive Impairment: A Randomized Controlled Trial

TypeinterventionalSponsorUniversity of British ColumbiaRan2009 to 2015Enrolled71ConditionsVascular Cognitive ImpairmentArmsAerobic-based exercise training, CON (control, usual care)
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jennifer C DavisDepartment of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.
Ging-Yuek Robin HsiungDepartment of Medicine, Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada.
Stirling BryanCentre for Clinical Epidemiology and Evaluation, University of British Columbia, Vancouver, British Columbia, Canada.
John R BestDepartment of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.
Janice J EngDepartment of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.
Michelle MunkacsyDepartment of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.
Winnie CheungDepartment of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.
Bryan ChiuDepartment of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.
Claudia JacovaDepartment of Medicine, Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada.
Philip LeeDepartment of Medicine, Division of Geriatric Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Teresa Liu-AmbroseDepartment of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.

Funding

CIHR
6 · The paper itself

Abstract

BACKGROUND/

objectivesEvidence suggests that aerobic exercise may slow the progression of subcortical ischaemic vascular cognitive impairment (SIVCI) by modifying cardiovascular risk factors. Yet the economic consequences relating to aerobic training (AT) remain unknown. Therefore, our primary objective was to estimate the incremental cost per quality-adjusted life years (QALYs) gained of a thrice weekly AT intervention compared with usual care.

designCost-utility analysis alongside a randomised trial.

settingVancouver, British Columbia, Canada.

participants70 adults (mean age of 74 years, 51% women) who meet the diagnostic criteria for mild SIVCI.

interventionA 6-month, thrice weekly, progressive aerobic exercise training programme compared with usual care (CON; comparator) with a follow-up assessment 6 months after formal cessation of aerobic exercise training. MEASUREMENTS: Healthcare resource usage was estimated over the 6-month intervention and 6-month follow-up period. Health status (using the EQ-5D-3L) at baseline and trial completion and 6-month follow-up was used to calculate QALYs. The incremental cost-utility ratio (cost per QALY gained) was calculated.

resultsQALYs were both modestly greater, indicating a health gain. Total healthcare costs (ie, 1791±1369 {2015 $CAD} at 6 months) were greater, indicating a greater cost for the thrice weekly AT group compared with CON. From the Canadian healthcare system perspective, the incremental cost-utility ratios for thrice weekly AT were cost-effective compared with CON, when using a willingness to pay threshold of $CAD 20 000 per QALY gained or higher.

conclusionsAT represents an attractive and potentially cost-effective strategy for older adults with mild SIVCI. TRIAL REGISTRATION NUMBER: NCT01027858.

Indexed as

AgedCanadaCognitive DysfunctionCost-Benefit AnalysisExerciseExercise TherapyFemaleHealth ResourcesHumansMaleOutcome Assessment, Health CareQuality-Adjusted Life YearsVascular Diseasesaerobic trainingcost-utility analysiseconomic evaluationexercisemild cognitive impairmentolder adults

Identifiers

PMID28360247
PMCPMC5372066

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.