ArticleJournal of the American Heart Association2017
Aortic Calcification Onset and Progression: Association With the Development of Coronary Atherosclerosis.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 55 citations in OpenAlex.
- Improving aortic calcium assessment in contrast-enhanced CT: exploring Hounsfield Unit thresholds for cardiovascular scoring.La Radiologia medica · 2026Article
- Serum free fatty acids and progression of coronary artery calcification: sex specific findings from a large U.S. cohort study.BMC cardiovascular disorders · 2026Article
- Routine preoperative screening computed tomography of the thorax for cardiac surgery.Singapore medical journal · 2026Article
- Elevated concentrations of cardiac troponin T are associated with thoracic aortic calcification in non-dialysis chronic kidney disease patients of stage G3 to G5.Renal failure · 2025Article
- Association of Muscle Radiodensity and Muscle Mass With Thoracic Aortic Calcification Progression in Dialysis Patients.Journal of cachexia, sarcopenia and muscle · 2025Article
- Growth Rate Assessed by Vascular Deformation Mapping Predicts Type B Aortic Dissection in Marfan Syndrome.Journal of the American Heart Association · 2025Article
- Long-term clinical significance of the presence of puff-chandelier ruptures detected by non-obstructive aortic angioscopy.Scientific reports · 2025Article
- Coarctation of the aorta and accelerated atherosclerosis: A contemporary review on the burden of atherosclerotic cardiovascular disease.International journal of cardiology. Congenital heart disease · 2025Article
- Growth Rate Assessed by Vascular Deformation Mapping predicts Type B Aortic Dissection in Marfan Syndrome.medRxiv : the preprint server for health sciences · 2024Article
- Aortic Arch Calcification Observed on Chest X-Ray May Serve as an Independent Predictor for Recurrent Stroke.Arquivos brasileiros de cardiologia · 2024Article
- Predictive factors of thoracic aortic calcification in patients candidate for cardiac surgery.Journal of cardiothoracic surgery · 2024Article
- Association between Aortic Calcification Burden and the Severity of Erectile Dysfunction in Men Undergoing Dialysis: A Cross-Sectional Study.The world journal of men's health · 2023Article
- Benign incidental cardiac findings in chest and cardiac CT imaging.The British journal of radiology · 2023Review
- Deep learning-based age estimation from chest X-rays indicates cardiovascular prognosis.Communications medicine · 2022Article
- Article
- Thoracic Aortic Calcification and Pre-Clinical Hypertension by New 2017 ACC/AHA Hypertension Guidelines.Diagnostics (Basel, Switzerland) · 2021Article
- Calcification prevalence in different vascular zones and its association with demographics, risk factors, and morphometry.American journal of physiology. Heart and circulatory physiology · 2021Article
- Per- and polyfluoroalkyl substances and calcifications of the coronary and aortic arteries in adults with prediabetes: Results from the diabetes prevention program outcomes study.Environment international · 2021Article
- Article
- Heritability of Cardiothoracic Ratio and Aortic Arch Calcification in Twins.Medicina (Kaunas, Lithuania) · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThoracic aortic calcification (TAC) and coronary artery calcification (CAC) are markers of subclinical atherosclerosis and are associated with incident major cardiovascular events. We investigated major determinants for incidence and progression of TAC and the association between TAC and CAC incidence and progression. METHODS AND
resultsIn a population-based cohort study, 3270 participants (aged 45-74 years, 53.1% women) received cardiac computed tomography at baseline and after a mean follow-up of 5.1±0.3 years for quantification of calcification of the ascending (ATAC) and descending thoracic aorta (DTAC) and CAC. Multivariable relative risk regression analysis was used to investigate associations of cardiovascular risk factors with incident TAC, of baseline TAC with incident CAC, and of baseline CAC with incident TAC. Of 1243 participants with baseline TAC of 0, 517 (41.6%) revealed incident TAC after 5 years. Incidence of descending TAC was higher (34.5%) than ascending TAC (23.3%). Incident TAC after 5 years was associated with age (relative risk 1.26 [95% CI 1.21-1.33], per 5 years), blood pressure (relative risk 1.06 [95% CI 1.03-1.10], per 10 mm Hg), low-density lipoprotein cholesterol (relative risk 1.08 [95% CI 1.04-1.12], per 20 mg/dL), and smoking (relative risk 1.28 [95% CI 1.07-1.53]). Among the 1185 participants without CAC at baseline, the risk of developing CAC was 28.3% when baseline TAC was present compared with 22.2% among those without baseline TAC (excess risk 6.1% [95% CI 1.2-11.0%]). The point estimate of excess risk for incident CAC was higher for ascending TAC (10.8% [95% CI 4.8-16.7%]) and low for descending TAC (1.8% [95% CI -3.2% to 6.7%]). Excess risk for developing ascending and descending TAC with present baseline CAC was 16.4% (95% CI 12.7-20.0%) and 15.6% (95% CI 10.8-20.4%), respectively.
conclusionTAC and CAC share similar major determinants for incident calcification. Participants with TAC, especially ascending TAC, are at elevated risk for development of CAC.
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