ArticleJournal of the American Society of Nephrology : JASN2017
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In one paragraph
Article in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.7field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Distinct osmoregulatory responses to sodium loading in patients with altered glycosaminoglycan structure: a randomized cross-over trial.Journal of translational medicine · 2021Trial
- Tonicity drives collecting duct maturation in the mammalian kidney.Nature communications · 2026Article
- The Osteoporotic Fractures in Men study (MrOS): a 25-yr landmark study of skeletal health in older men.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Genome-Wide Association Study of Plasma Sodium Concentrations with and without Exposure to Thiazide Diuretics.Journal of the American Society of Nephrology : JASN · 2025Article
- NFAT5: a stress-related transcription factor with multiple functions in health and disease.Cell stress · 2025Review
- Potential Theranostic Roles of SLC4 Molecules in Human Diseases.International journal of molecular sciences · 2023Review
- Direct ionic stress sensing and mitigation by the transcription factor NFAT5.bioRxiv : the preprint server for biology · 2023Article
- Dietary sodium enhances the expression of SLC4 family transporters, IRBIT, L-IRBIT, and PP1 in rat kidney: Insights into the molecular mechanism for renal sodium handling.Frontiers in physiology · 2023Article
- Analysis ofGenes · 2022Review
- UMOD and the architecture of kidney disease.Pflugers Archiv : European journal of physiology · 2022Review
- Plasma sodium, extracellular fluid volume, and blood pressure in healthy men.Physiological reports · 2021Observational
- Potential Use of Pharmacogenetics to Reduce Drug-Induced Syndrome of Inappropriate Antidiuretic Hormone (SIADH).Journal of personalized medicine · 2021Article
- Genetic Variants in Transcription Factor Binding Sites in Humans: Triggered by Natural Selection and Triggers of Diseases.International journal of molecular sciences · 2021Review
- Early Plasma Osmolality Levels and Clinical Outcomes in Children Admitted to the Pediatric Intensive Care Unit: A Single-Center Cohort Study.Frontiers in pediatrics · 2021Article
- Multiple acid-base and electrolyte disturbances upregulate NBCn1, NBCn2, IRBIT and L-IRBIT in the mTAL.The Journal of physiology · 2020Article
- The evolving role of TonEBP as an immunometabolic stress protein.Nature reviews. Nephrology · 2020Review
- Suboptimal hydration remodels metabolism, promotes degenerative diseases, and shortens life.JCI insight · 2019Article
- Heritability and individuality of the plasma sodium concentration: a twin study in the United States veteran population.American journal of physiology. Renal physiology · 2019Article
- A genome-wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine.Epilepsia open · 2019Article
- Expression, Localization, and Effect of High Salt Intake on Electroneutral NaFrontiers in physiology · 2019Article
Corrections and comments
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Authors and funding
106 authors at 1 institution in 1 country.
Carsten A BögerDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Mathias GorskiDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Gearoid M McMahonDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Huichun XuDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Yen-Pei C ChangDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Peter J van der MostDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Gerjan NavisDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Ilja M NolteDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Martin H de BorstDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Weihua ZhangDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Benjamin LehneDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Marie LohDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Sian-Tsung TanDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Eric BoerwinkleDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Morgan E GramsDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Peggy SekulaDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Man LiDue to the number of contributing authors, the affiliations are listed in the supplemental material. cohend@ohsu.edu.
Beth WilmotDue to the number of contributing authors, the affiliations are listed in the supplemental material.
James G MoonDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Paul ScheetDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Francesco CuccaDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Xiangjun XiaoDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Leo-Pekka LyytikäinenDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Graciela DelgadoDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Tanja B GrammerDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Marcus E KleberDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Sanaz SedaghatDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Fernando RivadeneiraDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Tanguy CorreDue to the number of contributing authors, the affiliations are listed in the supplemental material. cohend@ohsu.edu.
Zoltan KutalikDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Sven BergmannDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Carrie M NielsonDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Priya SrikanthDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Alexander TeumerDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Martina Müller-NurasyidDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Anne Catharina BrockhausDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Arne PfeuferDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Wolfgang RathmannDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Annette PetersDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Martha MatsumotoDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Mariza de AndradeDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Elizabeth J AtkinsonDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Cassianne Robinson-CohenDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Ian H de BoerDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Shih-Jen HwangDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Iris M HeidDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Martin GögeleDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Maria Pina ConcasDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Toshiko TanakaDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Stefania BandinelliDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Mike A NallsDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Andrew SingletonDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Salman M TajuddinDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Adebowale AdeyemoDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Jie ZhouDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Ayo DoumateyDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Shannon McWeeneyDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Joanne MurabitoDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Nora FranceschiniDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Michael FlessnerDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Michael ShlipakDue to the number of contributing authors, the affiliations are listed in the supplemental material.
James G WilsonDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Guanjie ChenDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Charles N RotimiDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Alan B ZondermanDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Michele K EvansDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Luigi FerrucciDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Olivier DevuystDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Mario PirastuDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Alan ShuldinerDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Andrew A HicksDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Peter Paul PramstallerDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Bryan KestenbaumDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Sharon L R KardiaDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Stephen T TurnerDue to the number of contributing authors, the affiliations are listed in the supplemental material.
LifeLines Cohort StudyDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Tamara Ellefson BriskeDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Christian GiegerDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Konstantin StrauchDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Christa MeisingerDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Thomas MeitingerDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Uwe VölkerDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Matthias NauckDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Henry VölzkeDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Peter VollenweiderDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Murielle BochudDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Gerard WaeberDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Mika KähönenDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Terho LehtimäkiDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Winfried MärzDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Abbas DehghanDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Oscar H FrancoDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Andre G UitterlindenDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Albert HofmanDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Herman A TaylorDue to the number of contributing authors, the affiliations are listed in the supplemental material.
John C ChambersDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Jaspal S KoonerDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Caroline S FoxDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Robert HitzemannDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Eric S OrwollDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Cristian PattaroDue to the number of contributing authors, the affiliations are listed in the supplemental material.
David SchlessingerDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Anna KöttgenDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Harold SniederDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Afshin ParsaDue to the number of contributing authors, the affiliations are listed in the supplemental material.
David M CohenDue to the number of contributing authors, the affiliations are listed in the supplemental material.
Oregon Health & Science University · US
Funding
Translational measures of risk for excessive alcohol consumptionP60AA010760 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI TAMARA J. PHILLIPS · 2006 to 2026
$34.5MAging-related Traits and Disease Risk Factors in a Sardinian Population CohortZIAAG000675 · NIA · NATIONAL INSTITUTE ON AGING · PI GOROSPE, MYRIAM · 2009 to 2021
$5.7MGenomic Predictors of Arteriosclerosis in HypertensivesR01HL087660 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARDIA, SHARON L · 2007 to 2009
$5.1MGenetic & Functional Analyses of Hypertension Susceptibility GenesR01HL088120 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI CHANG, YEN PEI CHRISTY · 2007 to 2017
$3.9MGenetic Mechanisms of Arteriosclerosis in Hypertensive SibshipsR01HL119443 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARDIA, SHARON L · 2014 to 2017
$2.1MNHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01 HL088120NHLBI NIH HHS R01 HL119443NIAAA NIH HHS P60 AA010760
Abstract
Disorders of water balance, an excess or deficit of total body water relative to body electrolyte content, are common and ascertained by plasma hypo- or hypernatremia, respectively. We performed a two-stage genome-wide association study meta-analysis on plasma sodium concentration in 45,889 individuals of European descent (stage 1 discovery) and 17,637 additional individuals of European descent (stage 2 replication), and a transethnic meta-analysis of replicated single-nucleotide polymorphisms in 79,506 individuals (63,526 individuals of European descent, 8765 individuals of Asian Indian descent, and 7215 individuals of African descent). In stage 1, we identified eight loci associated with plasma sodium concentration at
Indexed as
Genetic LociAgedFemaleGenome-Wide Association StudyHumansMaleMiddle AgedOsmolar ConcentrationPlasmaRacial GroupsSodiumSodium-Bicarbonate SymportersTranscription FactorsWater-Electrolyte ImbalanceNFAT5 protein, humanSLC4A10 protein, humanSodiumSodium-Bicarbonate SymportersTranscription Factorshuman geneticshypernatremiahyponatremiawater-electrolyte balance
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.