ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2017
In vitro and in vivo evaluation of a novel integrated wearable artificial lung.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- The Safety and Performance of a Novel Extracorporeal Membrane Oxygenation Device in a Long-Term Ovine Model.Advances in respiratory medicine · 2025Article
- Transplantation, bridging, and support technologies in pulmonary hypertension.The European respiratory journal · 2024Review
- A Wearable Extracorporeal COBioengineering (Basel, Switzerland) · 2024Article
- Ambulatory 7-day mechanical circulatory support in sheep model of pulmonary hypertension and right heart failure.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024Article
- A Portable Servoregulation Controller to Automate COBioengineering (Basel, Switzerland) · 2022Article
- The Roles of Membrane Technology in Artificial Organs: Current Challenges and Perspectives.Membranes · 2021Review
- Advances in extracorporeal membrane oxygenator design for artificial placenta technology.Artificial organs · 2021Review
- In vivo testing of the low-flow COIntensive care medicine experimental · 2020Article
- Evaluation of an autoregulatory ECMO system for total respiratory support in an acute ovine model.Artificial organs · 2020Article
- In Vitro models for thrombogenicity testing of blood-recirculating medical devices.Expert review of medical devices · 2019Review
- In Vivo 5 Day Animal Studies of a Compact, Wearable Pumping Artificial Lung.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2019Article
- Cell-based Therapy for Chronic Obstructive Pulmonary Disease. Rebuilding the Lung.Annals of the American Thoracic Society · 2018Review
- Bench Validation of a Compact Low-Flow COIntensive care medicine experimental · 2018Article
- In Vitro Characterization of the Pittsburgh Pediatric Ambulatory Lung.ASAIO journal (American Society for Artificial Internal Organs : 1992)Article
Corrections and comments
- Erratum issuedErratum.2017
Authors and funding
7 authors.
Funding
Abstract
backgroundConventional extracorporeal membrane oxygenation (ECMO) is cumbersome and is associated with high morbidity and mortality. We are currently developing the Pittsburgh Ambulatory Assist Lung (PAAL), which is designed to allow for ambulation of lung failure patients during bridge to transplant or recovery. In this study, we investigated the in vitro and acute in vivo performance of the PAAL.
methodsThe PAAL features a 1.75-inch-diameter, cylindrical, hollow-fiber membrane (HFM) bundle of stacked sheets, with a surface area of 0.65 m
resultsThe PAAL pumped >250 mm Hg at 3.5 liters/min at a rotation speed of 2,100 rpm. Oxygenation performance met the target of 180 ml/min at 3.5 liters/min of blood flow in vitro, resulting in a gas-exchange efficiency of 278 ml/min/m
conclusionThe PAAL met in vitro and acute in vivo performance targets. Five-day chronic sheep studies are planned for the near future.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.