Evidence map›Paper›PMID 28359584›Full record

ReviewTrends in genetics : TIG2017

Specialize and Divide (Twice): Functions of Three Aurora Kinase Homologs in Mammalian Oocyte Meiotic Maturation.

Alexandra L Nguyen, Karen Schindler

Abstract readReview
In one paragraph

Review in Trends in genetics : TIG, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Genetic interaction mapping of Aurora protein kinases in mouse oocytes.Frontiers in cell and developmental biology · 2024
    Article
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  13. Review
  14. Article
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  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alexandra L NguyenDepartment of Genetics, Rutgers University, 145 Bevier Road, Piscataway, NJ 08854, USA.
Karen SchindlerDepartment of Genetics, Rutgers University, 145 Bevier Road, Piscataway, NJ 08854, USA. Electronic address: schindler@biology.rutgers.edu.
Rutgers, The State University of New Jersey · US

Funding

Control of mammalian meiosis I through protein kinase signalingR01GM112801 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI SCHINDLER, KAREN A · 2015 to 2019
$1.9M
Investigating the discrete functions of the aurora kinases in meiosis IF31HD089597 · NICHD · RUTGERS, THE STATE UNIV OF N.J. · PI NGUYEN, ALEXANDRA A · 2016 to 2017
$75k
NICHD NIH HHS F31 HD089597NIGMS NIH HHS R01 GM112801
6 · The paper itself

Abstract

The aurora kinases (AURKs) comprise an evolutionarily conserved family of serine/threonine kinases involved in mitosis and meiosis. While most mitotic cells express two AURK isoforms (AURKA and AURKB), mammalian germ cells also express a third, AURKC. Although much is known about the functions of the kinases in mitosis, less is known about how the three isoforms function to coordinate meiosis. This review is aimed at describing what is known about the three isoforms in female meiosis, the similarities and differences between kinase functions, and speculates as to why mammalian germ cells require expression of three AURKs instead of two.

Indexed as

AnimalsAurora Kinase AAurora Kinase BAurora Kinase CFemaleGene Expression Regulation, DevelopmentalGerm CellsHumansMeiosisMiceOocytesOogenesisAurka protein, mouseAurkb protein, mouseAurkc protein, mouseAurora Kinase AAurora Kinase BAurora Kinase Caurora kinasechromosomal passenger complexmeiosisoocyte

Identifiers

PMID28359584
PMCPMC5435372
OpenAlexW2600847410

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.