Trial reportJournal of the American College of Cardiology2017
Exercise Training in Patients With Chronic Heart Failure and Atrial Fibrillation.
Trial report in Journal of the American College of Cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00047437 (Heart Failure), which is not on this map. Cited by 34 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION)
Who cites it
34 citing papers in PubMed, 10 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Pooled it
- Efficacy of exercise intervention for atrial fibrillation: a systematic review and meta-analysis.BMC cardiovascular disorders · 2025Pooled it
- Effect of exercise intervention on quality of life and exercise capacity in patients with atrial fibrillation: a systematic review and network meta-analysis.Frontiers in public health · 2025Pooled it
- Exercise-based cardiac rehabilitation for adults with atrial fibrillation.The Cochrane database of systematic reviews · 2024Pooled it
- Exercise-based cardiac rehabilitation for adults with heart failure.The Cochrane database of systematic reviews · 2024Pooled it
- Guideline
- 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.Journal of the American College of Cardiology · 2024Guideline
- Exercise-based cardiac rehabilitation for adults with heart failure.The Cochrane database of systematic reviews · 2019Pooled it
- Meta-Analysis of the Effects of Cardiac Rehabilitation on Exercise Tolerance and Cardiac Function in Heart Failure Patients Undergoing Cardiac Resynchronization Therapy.BioMed research international · 2019Pooled it
- Meta-analysis of randomized controlled trials on atrial fibrillation ablation in patients with heart failure with reduced ejection fraction.Clinical cardiology · 2018Pooled it
- Atrial Fibrillation Status and Physical Rehabilitation in Older Patients With Acute Decompensated Heart Failure: An Analysis From the REHAB-HF Trial.Journal of the American Heart Association · 2024Trial
- Association between atrial fibrillation and heart failure patient reported outcomes across the ejection fraction spectrum.American heart journal · 2024Trial
- Personalized smart voice-based electronic prescription for remote at-home feedback management in cardiovascular disease rehabilitation: a multi-center randomized controlled trial.Frontiers in public health · 2023Trial
- High-intensity interval training attenuates cardiac injury by targeting ferroptosis and endoplasmic reticulum-stress in male rats with heart failure.Physiological reports · 2025Article
- JCS/JHRS 2024 Guideline Focused Update on Management of Cardiac Arrhythmias.Journal of arrhythmia · 2025Article
- Exercise-based cardiac rehabilitation for patients with atrial fibrillation: a narrative review.European heart journal open · 2025Review
- The impact of atrial fibrillation on oxygen uptake and haemodynamics in patients with heart failure: a systematic review and meta-analysis.European heart journal open · 2025Article
- Atrial Fibrillation in Elite Athletes: A Comprehensive Review of the Literature.Journal of cardiovascular development and disease · 2024Review
- Physical activity and the risk of developing 8 age-related diseases: epidemiological and Mendelian randomization studies.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2024Article
- Exercise training outcomes in patients with chronic heart failure with reduced ejection fraction depend on patient background.Frontiers in cardiovascular medicine · 2024Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundThe safety and efficacy of aerobic exercise in heart failure (HF) patients with atrial fibrillation (AF) has not been well evaluated.
objectivesThis study examined whether outcomes with exercise training in HF vary according to AF status.
methodsHF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) randomized 2,331 ambulatory HF patients with ejection fraction ≤35% to exercise training or usual care. We examined clinical characteristics and outcomes (mortality/hospitalization) by baseline AF status (past history of AF or AF on baseline electrocardiogram vs. no AF) using adjusted Cox models and explored an interaction with exercise training. We assessed post-randomization AF events diagnosed via hospitalizations for AF and reports of serious arrhythmia caused by AF.
resultsOf 2,292 patients with baseline rhythm data, 382 (17%) had AF, 1,602 (70%) had sinus rhythm, and 308 (13%) had "other" rhythm. Patients with AF were older and had lower peak Vo
conclusionsAF in patients with chronic HF was associated with older age, reduced exercise capacity at baseline, and a higher overall rate of clinical events, but not a differential response to exercise training for clinical outcomes or changes in exercise capacity. (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training [HF-ACTION]; NCT00047437).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.