ArticleAlzheimer's research & therapy2017
Memory performance-related dynamic brain connectivity indicates pathological burden and genetic risk for Alzheimer's disease.
Article in Alzheimer's research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Globus Pallidus Iron Relates to Cognitive Impairment in Alzheimer's Disease: Evidence From MRI-Based Meta-Analysis.Annals of the New York Academy of Sciences · 2026Pooled it
- Capturing silent oxidative stress in early Alzheimer's disease: prediction of CSF biomarkers from sleep qEEG data.GeroScience · 2026Article
- A local-to-distant shift in dynamic brain connectivity marks early Alzheimer's risk.GeroScience · 2026Article
- Depthwise cortical iron relates to functional connectivity and fluid cognition in healthy aging.Neurobiology of aging · 2025Article
- Functional network centrality indicates interactions between APOE4 and age across the clinical spectrum of Alzheimer's Disease.NeuroImage. Clinical · 2024Article
- Genetic basis of anatomical asymmetry and aberrant dynamic functional networks in Alzheimer's disease.Brain communications · 2024Article
- Review
- Source connectivity patterns in the default mode network differ between elderly golf-novices and non-golfers.Scientific reports · 2023Article
- Environmental effects on brain functional networks in a juvenile twin population.Scientific reports · 2023Article
- Impaired time-distance reconfiguration patterns in Alzheimer's disease: a dynamic functional connectivity study with 809 individuals from 7 sites.BMC bioinformatics · 2022Article
- Asthma's effect on brain connectivity and cognitive decline.Frontiers in neurology · 2022Article
- Tools of the trade: estimating time-varying connectivity patterns from fMRI data.Social cognitive and affective neuroscience · 2021Review
- Alterations in Dynamic Functional Connectivity in Individuals With Subjective Cognitive Decline.Frontiers in aging neuroscience · 2021Article
- Current methods and new directions in resting state fMRI.Clinical imaging · 2020Review
- Alteration of functional connectivity in patients with Alzheimer's disease revealed by resting-state functional magnetic resonance imaging.Neural regeneration research · 2020Article
- Functional Brain Network Connectivity Patterns Associated With Normal Cognition at Old-Age, Local β-amyloid, Tau, and APOE4.Frontiers in aging neuroscience · 2020Article
- Increased cerebral blood volume in small arterial vessels is a correlate of amyloid-β-related cognitive decline.Neurobiology of aging · 2019Article
- Background field removal for susceptibility mapping of human brain with large susceptibility variations.Magnetic resonance in medicine · 2019Article
- Dynamic Functional Magnetic Resonance Imaging Connectivity Tensor Decomposition: A New Approach to Analyze and Interpret Dynamic Brain Connectivity.Brain connectivity · 2019Article
- Changes in Centrality Frequency of the Default Mode Network in Individuals With Subjective Cognitive Decline.Frontiers in aging neuroscience · 2019Article
Corrections and comments
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Authors and funding
20 authors.
Funding
Abstract
backgroundThe incidence of Alzheimer's disease (AD) strongly relates to advanced age and progressive deposition of cerebral amyloid-beta (Aβ), hyperphosphorylated tau, and iron. The purpose of this study was to investigate the relationship between cerebral dynamic functional connectivity and variability of long-term cognitive performance in healthy, elderly subjects, allowing for local pathology and genetic risk.
methodsThirty seven participants (mean (SD) age 74 (6.0) years, Mini-Mental State Examination 29.0 (1.2)) were dichotomized based on repeated neuropsychological test performance within 2 years. Cerebral Aβ was measured by
resultsA relationship between low episodic memory and a lower expression of anterior-posterior connectivity was seen (F(9,27) = 3.23, p < 0.008), moderated by ApoE-ε4 (F(9,27) = 2.22, p < 0.005). Inherent node-strength was related to local iron (F(5,30) = 13.2; p < 0.022).
conclusionOur data indicate that altered dynamic anterior-posterior brain connectivity is a characteristic of low memory performance in the subclinical range and genetic risk for AD in the elderly. As the observed altered brain network properties are associated with increased local iron, our findings may reflect secondary neuronal changes due to pathologic processes including oxidative stress.
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