Evidence map›Paper›PMID 28359212›Full record

Trial reportAIDS care2017

A randomized clinical trial of adolescents with HIV/AIDS: pediatric advance care planning.

Maureen E Lyon, Lawrence J D'Angelo, Ronald H Dallas, Pamela S Hinds, Patricia A Garvie, Megan L Wilkins, Ana Garcia, Linda Briggs, Patricia M Flynn, Sohail R Rana and 2 more

2 registry-linked trialsAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 7 pooled it
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01289444 nacompletednot on this map

Longitudinal Pediatric Palliative Care: Quality of Life & Spiritual Struggle

TypeinterventionalSponsorMaureen LyonRan2011 to 2014Enrolled216ConditionsHIVArmsFAmily CEntered (FACE) ACP, Healthy Living Control
NCT02693665 nacompletednot on this map

Building Evidence for Effective Palliative/End of Life Care for Teens With Cancer

TypeinterventionalSponsorMaureen LyonRan2016 to 2022Enrolled260ConditionsCancerArmsFAmily CEntered Advance Care Planning for Teens with Cancer
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 7 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
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  6. A Systematic Review and Meta-Analysis of Interventions for Orphans and Vulnerable Children Affected by HIV/AIDS Worldwide.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2020
    Pooled it
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  8. Trial
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  14. Review
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  18. The Effect of FAmily-CEntered (FACEJournal of family nursing · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Maureen E Lyona Department of Pediatrics , Children's National, Children's Research Institute, Center for Translational Science and George Washington University School of Medicine and Health Sciences , Washington , USA.
Lawrence J D'Angelob Department of Pediatrics, Children's National, Division of Adolescent & Young Adult Medicine , George Washington University School of Medicine and Health Sciences , Washington , USA.
Ronald H Dallasc Department of Infectious Diseases , St. Jude Children's Research Hospital , Memphis , USA.
Pamela S Hindsa Department of Pediatrics , Children's National, Children's Research Institute, Center for Translational Science and George Washington University School of Medicine and Health Sciences , Washington , USA.
Patricia A Garvied Research Department , Children's Diagnostic & Treatment Center , Fort Lauderdale , USA.
Megan L Wilkinsc Department of Infectious Diseases , St. Jude Children's Research Hospital , Memphis , USA.
Ana Garciae Pediatric Infectious Disease & Immunology , University of Miami Miller School of Medicine , Miami , USA.
Linda Briggsf Gundersen Lutheran Medical Foundation, Inc ., La Crosse , USA.
Patricia M Flynnc Department of Infectious Diseases , St. Jude Children's Research Hospital , Memphis , USA.
Sohail R Ranag Department of Pediatrics and Child Health , Howard University Hospital , Washington , USA.
Yao Iris Chengh Division of Biostatistics and Study Methodology , Children's National, Children's Research Institute, Center for Translational Science , Washington , USA.
Jichuan Wangh Division of Biostatistics and Study Methodology , Children's National, Children's Research Institute, Center for Translational Science , Washington , USA.
St. Jude Children's Research Hospital · USChildren’s Institute · USChildren's National · USChildren's Diagnostic & Treatment Center · USGeorge Washington University · USHoward University Hospital · USUniversity of Miami · US

Funding

Longitudinal Pediatric Palliative Care: Quality of Life & Spiritual StruggleR01NR012711 · NINR · CHILDREN'S RESEARCH INSTITUTE · PI LYON, MAUREEN ELLEN · 2010 to 2014
$2.9M
NINR NIH HHS R01 NR012711
6 · The paper itself

Abstract

The objective of this study is to determine if pediatric advance care planning (pACP) increases adolescent/family congruence in end-of-life (EOL) treatment preferences longitudinally. Adolescents aged 14-21 years with HIV/AIDS and their families were randomized (N = 105 dyads) to three-60-minute sessions scheduled one week apart: either the pACP intervention (survey administered independently, facilitated conversation with adolescent and family present, completion of legal advance directive document with adolescent and family present) or an active control (developmental history, safety tips, nutrition and exercise education). This longitudinal, single-blinded, multi-site, randomized controlled trial was conducted in six pediatric hospital-based HIV-clinics, located in high HIV mortality cities. The Statement of Treatment Preferences measured adolescent/family congruence in EOL treatment preferences at immediately following the facilitated pACP conversation (Session 2), and at 3-month post-intervention. The mean age of adolescent participants was 18 years (range 14-21 years); 54% were male; and 93% were African-American. One-third had an AIDS diagnosis. Immediately post-intervention the Prevalence Adjusted Bias Adjusted Kappa showed substantial treatment preference agreement for pACP dyads compared to controls (High burden/low chance of survival, PABAK = 0.688 vs. 0.335; Functional impairment, PABAK = 0.687 vs. PABAK= 0.34; Mental impairment, PABKA = 0.717 vs. 0.341). Agreement to limit treatments was greater among intervention dyads than controls (High burden: 14.6% vs. 0%; Functional impairment = 22.9% vs. 4.4%; and Mental impairment: 12.5% vs. 4.4%). Overall treatment preference agreement among pACP dyads was high immediately post-intervention, but decreased over time. In contrast, treatment agreement among control dyads was low and remained low over time. As goals of care change over time with real experiences, additional pACP conversations are needed.

Indexed as

Advance Care PlanningDecision MakingAcquired Immunodeficiency SyndromeAdolescentAdvance DirectivesChildCommunicationFamilyFemaleHIV InfectionsHospitals, PediatricHumansMalePatient Acceptance of Health CareSingle-Blind MethodSurveys and QuestionnairesAdvance care planningcongruencedecision-makingend-of-lifepalliative carepediatric

Identifiers

PMID28359212
PMCPMC5846623
OpenAlexW2598605935

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.